Cloutier Gabriel, Sallenbach-Morrissette Amélie, Beaulieu Jean-François
Laboratory of Intestinal Physiopathology, Department of Anatomy & Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.
Tissue Cell. 2019 Feb;56:71-78. doi: 10.1016/j.tice.2018.12.005. Epub 2018 Dec 21.
The interactions between cells and the extracellular matrix (ECM) play a major role in normal and pathological conditions. The ECM can modulate several biological functions including cell proliferation, adhesion, differentiation and survival through its interactions with cell receptors. Laminins are one of the most important glycoproteins present in basement membranes, a type of ECM. The pattern of expression of its different isoforms depends on the spatiotemporal organization of each tissue. While integrins are the most studied laminin receptors, other non-integrin laminin receptors are also involved. This review focuses on two particular non-integrin laminin receptors in the epithelial context: dystroglycan and 37/67 laminin receptor (37/67LR). Dystroglycan is a two-subunit protein discovered in the muscle as part of the dystrophin-associated glycoprotein complex. This protein can also be found in many epithelia where its roles are variable. The 37/67LR is a still incompletely understood laminin receptor that is important to regulate intestinal epithelial cell function and could be involved in various pathological conditions.
细胞与细胞外基质（ECM）之间的相互作用在正常和病理状态中起着主要作用。ECM可通过与细胞受体的相互作用调节多种生物学功能，包括细胞增殖、黏附、分化和存活。层粘连蛋白是基底膜（一种ECM）中存在的最重要的糖蛋白之一。其不同亚型的表达模式取决于每个组织的时空组织。虽然整合素是研究最多的层粘连蛋白受体，但其他非整合素层粘连蛋白受体也参与其中。本综述聚焦于上皮环境中的两种特定非整合素层粘连蛋白受体：肌营养不良蛋白聚糖和37/67层粘连蛋白受体（37/67LR）。肌营养不良蛋白聚糖是一种在肌肉中发现的双亚基蛋白，是肌营养不良蛋白相关糖蛋白复合物的一部分。这种蛋白也可在许多上皮组织中发现，其作用各不相同。37/67LR是一种尚未完全了解的层粘连蛋白受体，对调节肠道上皮细胞功能很重要，可能参与各种病理状况。
