Tunggal P, Smyth N, Paulsson M, Ott M C
Institute for Biochemistry, Medical Faculty, University of Cologne, D-50931 Cologne, Germany.
Microsc Res Tech. 2000 Nov 1;51(3):214-27. doi: 10.1002/1097-0029(20001101)51:3<214::AID-JEMT2>3.0.CO;2-J.
The laminins form a large family of modular proteins found in basement membranes, but also elsewhere. They function as structural components and are essential for morphogenesis, but in addition interact with cell surface receptors such as integrins and alpha-dystroglycan. By virtue of their receptor interactions, they initiate intracellular signalling events that regulate cellular organization and differentiation. The many interactions of laminins are mediated by binding sites, often contributed by single domains, which may differ between different forms of laminin. In the present article, we describe how the diversity of laminins and the genetic regulation of the expression of different laminin forms lead to the formation of extracellular matrices with variable laminin composition and thereby different biological properties.
层粘连蛋白构成了一个庞大的模块化蛋白质家族，不仅存在于基底膜中，也存在于其他地方。它们作为结构成分发挥作用，对形态发生至关重要，此外还与整合素和α- dystroglycan等细胞表面受体相互作用。凭借其与受体的相互作用，它们引发调节细胞组织和分化的细胞内信号事件。层粘连蛋白的许多相互作用是由结合位点介导的，这些结合位点通常由单个结构域提供，不同形式的层粘连蛋白之间可能有所不同。在本文中，我们描述了层粘连蛋白的多样性以及不同层粘连蛋白形式表达的基因调控如何导致具有可变层粘连蛋白组成从而具有不同生物学特性的细胞外基质的形成。
