Fahr A, Langer R, Sziegoleit W, Albert H, Liebal H, Mest H J
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
Biomed Biochim Acta. 1988;47(10-11):S238-40.
The influence of pentoxifylline on the synthesis of prostacyclin (PGI2) was studied using human varicose veins removed by a stripping operation. Patients got 100 mg pentoxifylline iv. during the operation. The synthesis of PGI2 was studied according to the inhibition of the ADP-induced platelet aggregation without and with addition of substrate (100 ng prostaglandinendoperoxide H2) to the incubation fluid. There were no changes in the synthesis of PGI2 compared to control values.
使用通过剥脱手术切除的人体静脉曲张研究己酮可可碱对前列环素（PGI2）合成的影响。患者在手术期间静脉注射100毫克己酮可可碱。根据在孵育液中添加和不添加底物（100纳克前列腺素内过氧化物H2）时对ADP诱导的血小板聚集的抑制作用来研究PGI2的合成。与对照值相比，PGI2的合成没有变化。
