Burdo Tricia H
Department of Neuroscience, Temple University School of Medicine, 3500 North Broad Street, MERB 755, Philadelphia, PA, 19140, USA.
J Neuroimmune Pharmacol. 2019 Mar;14(1):2-5. doi: 10.1007/s11481-019-09836-3. Epub 2019 Feb 9.
Macrophages as reservoirs for persistent HIV infection has gained renewed importance, with an intense research focus dedicated to eradication strategies. Clearance of both latent and productive HIV from these important reservoirs is essential for successful eradication. This spe cial theme issue contains 11 papers, including 6 Invited Reviews, 1 Brief Report and 4 Original Articles, that focus on the various aspects of the macrophage as pertains to HIV persistence, latency and cure. These topics include: functional latency of macrophages and microglia, the link between peripheral monocytes and pathogenesis, macrophages as sources of HIV RNA and DNA in virally suppressed patients, brain imaging of neuroinflammation, macrophages as drug delivery vehicles, therapeutic strategies of infected macrophages for cure, and the role of drugs of abuse in enhancing macrophage viral persistence.
巨噬细胞作为持续性HIV感染的储存库已重新受到重视，目前有大量研究致力于根除策略。从这些重要储存库中清除潜伏性和活跃性HIV对于成功根除至关重要。本期专题包含11篇论文，其中包括6篇特邀综述、1篇简报和4篇原创文章，重点关注巨噬细胞与HIV持续存在、潜伏及治愈相关的各个方面。这些主题包括：巨噬细胞和小胶质细胞的功能性潜伏、外周单核细胞与发病机制之间的联系、巨噬细胞作为病毒抑制患者体内HIV RNA和DNA来源、神经炎症的脑成像、巨噬细胞作为药物递送载体、感染巨噬细胞的治愈治疗策略以及药物滥用在增强巨噬细胞病毒持续性中的作用。
