通过成人颅骨的微波热声断层成像。
Microwave-induced thermoacoustic tomography through an adult human skull.
机构信息
School of Electronics and Information Engineering, Sichuan University, Chengdu, 610064, China.
Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng, Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
出版信息
Med Phys. 2019 Apr;46(4):1793-1797. doi: 10.1002/mp.13439. Epub 2019 Feb 25.
PURPOSE
To demonstrate the feasibility of microwave-induced thermoacoustic tomography (TAT) of adult human brain.
METHODS
We analyzed the electric field distribution radiated from an antenna to acquire homogeneous illumination. We first imaged the anatomical structures in a rat's trunk to validate the thermoacoustic contrast in vivo. We then imaged an agar cylinder through an adult human skull ex vivo to demonstrate transcranial penetration of both microwave and ultrasound. We also analyzed the specific absorption rate to show the conformance to the safety standard for human electromagnetic exposure.
RESULTS
We successfully acquired cross-sectional images of the rat's trunk in vivo. Major blood vessels and organs are clearly visible. The transcranial image shows that TAT can image through the adult human skull and reveal an agar enclosed by the skull.
CONCLUSIONS
Microwave-induced TAT of a rat's trunk in vivo and an agar phantom through an adult human skull ex vivo has been demonstrated experimentally. This study demonstrates both the TAT contrasts in vivo and the capability of transcranial imaging, showing potential of TAT for adult human brain imaging with high contrast and penetration.
目的
展示用于成人脑部的微波激励热声层析成像（TAT）的可行性。
方法
我们分析了天线辐射的电场分布，以获得均匀的照明。我们首先对大鼠躯干的解剖结构进行成像，以验证体内热声对比。然后，我们通过成人颅骨对琼脂柱进行成像，以证明微波和超声都能穿透颅腔。我们还分析了比吸收率，以表明符合人体电磁辐射暴露的安全标准。
结果
我们成功地获得了大鼠躯干的横截面体内图像。主要血管和器官清晰可见。颅外图像显示 TAT 可以穿透成人颅骨，并显示颅骨内包裹的琼脂。
结论
实验证明了大鼠躯干的体内微波激励 TAT 和成人颅骨外的琼脂体模成像。本研究展示了体内 TAT 对比和颅穿透成像的能力，表明 TAT 具有高对比度和穿透性，用于成人脑部成像的潜力。
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