Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Nat Rev Clin Oncol. 2022 Jun;19(6):365-384. doi: 10.1038/s41571-022-00615-3. Epub 2022 Mar 23.
Clinical oncology can benefit substantially from imaging technologies that reveal physiological characteristics with multiscale observations. Complementing conventional imaging modalities, photoacoustic imaging (PAI) offers rapid imaging (for example, cross-sectional imaging in real time or whole-breast scanning in 10-15 s), scalably high levels of spatial resolution, safe operation and adaptable configurations. Most importantly, this novel imaging modality provides informative optical contrast that reveals details on anatomical, functional, molecular and histological features. In this Review, we describe the current state of development of PAI and the emerging roles of this technology in cancer screening, diagnosis and therapy. We comment on the performance of cutting-edge photoacoustic platforms, and discuss their clinical applications and utility in various clinical studies. Notably, the clinical translation of PAI is accelerating in the areas of macroscopic and mesoscopic imaging for patients with breast or skin cancers, as well as in microscopic imaging for histopathology. We also highlight the potential of future developments in technological capabilities and their clinical implications, which we anticipate will lead to PAI becoming a desirable and widely used imaging modality in oncological research and practice.
临床肿瘤学可以从能够提供多尺度观察的生理特征的成像技术中获得实质性的收益。光声成像（PAI）作为传统成像方式的补充，具有快速成像（例如实时的横截面成像或 10-15 秒内的全乳扫描）、可扩展的高空间分辨率、安全的操作和可适应的配置等优点。最重要的是，这种新型成像方式提供了有意义的光学对比度，可以揭示解剖学、功能、分子和组织学特征的细节。在这篇综述中，我们描述了 PAI 的当前发展状况以及该技术在癌症筛查、诊断和治疗方面的新兴作用。我们对最先进的光声平台的性能进行了评论，并讨论了它们在各种临床研究中的临床应用和实用性。值得注意的是，PAI 在乳腺癌或皮肤癌的宏观和介观成像领域以及组织病理学的微观成像领域的临床转化正在加速。我们还强调了技术能力的未来发展及其临床意义的潜力，我们预计这将导致 PAI 成为肿瘤学研究和实践中理想且广泛使用的成像方式。
