Department of Cardiology, Erzurum Training and Research Hospital, Erzurum, Turkey.
Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey.
J Clin Lab Anal. 2019 May;33(4):e22848. doi: 10.1002/jcla.22848. Epub 2019 Feb 8.
Although interventional methods are the first-line treatment options in ST-segment elevation myocardial infarction (STEMI), the incidence of stent restenosis (SR) is frequent. We investigated the relationship between CRP/albumin ratio (CAR), a novel indicator of inflammatory response, and SR in this study.
This study was carried out on the patients who underwent coronary angiography in our clinic between January 2017 and September 2017. Two groups were generated according to restenosis status (group 1: restenosis (-), group 2: restenosis (+)), and clinical biochemical and angiographical features were compared. As baseline demographic and angiographic characteristics are slightly different in two groups, propensity score matching analysis was performed to reduce bias. 45 SR patients were matched on a 1:1 basis were enrolled final cohort.
The mean age of the patients was 55 ± 5.1 and 80% were male; Cox regression model was performed to demonstrate independent predictor of restenosis development; and during the one-year follow-up period, CAR (P < 0.001) was found an independent predictor of SR CONCLUSION: In this study, we demonstrate that there may be a strong relationship between SR development and CAR. We implied that inflammatory reaction may be an important diagnostic tool for prediction of SR development in STEMI patients.
尽管介入方法是 ST 段抬高型心肌梗死（STEMI）的首选治疗方法，但支架再狭窄（SR）的发生率仍然较高。本研究旨在探讨新型炎症反应标志物 C 反应蛋白/白蛋白比值（CAR）与 SR 之间的关系。
该研究纳入了 2017 年 1 月至 2017 年 9 月期间在我院接受冠状动脉造影的患者。根据再狭窄情况将患者分为两组（组 1：无再狭窄，组 2：有再狭窄），比较两组患者的临床生化和血管造影特征。由于两组患者的基线人口统计学和血管造影特征存在差异，因此采用倾向评分匹配分析来减少偏倚。最终纳入了 45 例 SR 患者和 45 例匹配患者。
患者的平均年龄为 55 ± 5.1 岁，80%为男性；Cox 回归模型显示，再狭窄的独立预测因子为 CAR（P < 0.001）。在为期一年的随访期间，CAR 是 SR 的独立预测因子。
本研究表明，SR 的发生与 CAR 之间可能存在密切关系。我们推测炎症反应可能是预测 STEMI 患者 SR 发生的重要诊断工具。
