Głogowska-Szeląg Joanna
Zakład Patofizjologii, Katedra Patofizjologii i Endokrynologii, Śląski Uniwersytet Medyczny, Zabrze, Polska.
Wiad Lek. 2018;71(9):1714-1718.
Introduction: Osteoporosis is chronic metabolic disease of the bone-joint system and it is increase risk of bone fractures and mortality. The effect of postmenopausal hormonal changes can be the adipose tissue gain along. Osteoporosis and decreased BMD in women with menopause can be a result of the change of body mass. Previous studies have demonstrated protective effect of high values of BMI on the bone tissue, may be which protect against osteoporosis. The aim: The assessment of BMD in a connection with the body mass index BMI in women with postmenopausal osteoporosis.
Materials and methods: The researches have been conducted on 120 selected postmenopausal women who were diagnosed with osteoporosis after analysis of the risk factors and carrying out the bone densitometry test - DXA method. The patients were divided into three research groups each comprising with 40 persons, depending on the body mass index BMI.. The first group were postmenopausal women with osteoporosis and with the value of BMI 18-24.9,indicating normal range; second group were postmenopausal women with osteoporosis with the value of BMI 25-29.9,indicating overweight and the third group were postmenopausal women with osteoporosis with the value BMI 30-34.9, indicating obesity.
Results: In the group of postmenopausal women with osteoporosis with a BMI value corresponding to obesity, the mean BMD was 0.82 g/cm2. In the overweight and normal body mass index group there were no statistically significant differences in the values obtained, which are 0.78 and 0.79 g/cm2, respectively. The correlation analysis showed a statistically significant positive relationship - the increase in BMI was accompanied by the increasing BMD in the entire study population. The T-score in the densitometric study in relation to BMD was the lowest in people with normal BMI and comparable in the overweight group, while the highest in obese women.
Conclusions: Of the results of the research: postmenopausal women with osteoporosis confirmed the relationship that there are higher BMD values with increasis BMI values. From the other side owerweight and obesity may determine an intensification of osteoporosis in postmenopausal women.
引言：骨质疏松症是一种骨关节系统的慢性代谢性疾病，会增加骨折风险和死亡率。绝经后激素变化的影响可能伴随着脂肪组织增加。绝经后女性骨质疏松症和骨密度降低可能是体重变化的结果。先前的研究表明，高体重指数对骨组织有保护作用，可能有助于预防骨质疏松症。目的：评估绝经后骨质疏松症女性的骨密度与体重指数（BMI）之间的关系。
材料与方法：对120名经风险因素分析及骨密度测定（双能X线吸收法，DXA法）确诊为骨质疏松症的绝经后女性进行了研究。根据体重指数（BMI）将患者分为三个研究组，每组40人。第一组为绝经后骨质疏松症女性，BMI值为18 - 24.9，表明在正常范围内；第二组为绝经后骨质疏松症女性，BMI值为25 - 29.9，表明超重；第三组为绝经后骨质疏松症女性，BMI值为30 - 34.9，表明肥胖。
结果：在BMI值对应肥胖的绝经后骨质疏松症女性组中，平均骨密度为0.82g/cm²。在超重和正常体重指数组中，所获数值分别为0.78g/cm²和0.79g/cm²，无统计学显著差异。相关性分析显示存在统计学显著的正相关关系——在整个研究人群中，BMI增加伴随着骨密度增加。骨密度测定研究中与骨密度相关的T值在正常BMI人群中最低，在超重组中相当，而在肥胖女性中最高。
结论：根据研究结果：绝经后骨质疏松症女性证实了骨密度值随BMI值增加而升高的关系。另一方面，超重和肥胖可能会加剧绝经后女性的骨质疏松症。
