Li Li, Ge Ji-Rong, Chen Juan, Ye Yun-Jin, Xu Peng-Chao, Li Jian-Yang
Fujian University of Traditional Chinese Medicine.
Fujian Academy of Chinese Medical Sciences, Fuzhou, Fujian Province, China.
Medicine (Baltimore). 2020 Jul 10;99(28):e20906. doi: 10.1097/MD.0000000000020906.
Osteoporosis (OP) is a metabolic bone disease that can cause structural changes in bone marrow cavity. Bone marrow is the hematopoietic organ of adults. Accumulating evidence has shown a close connection between bone marrow hematopoietic function and bone formation. Some studies have revealed that OP is associated with hematopoiesis. However, the relationship is not definite.This study aimed to evaluate the association between peripheral blood cell counts (white blood cells [WBC], red blood cells [RBC], platelets [PLT]), hemoglobin [HGB], and bone mineral density [BMD]) in a sample of Chinese postmenopausal women. This is a retrospective study involving 673 postmenopausal women cases. The BMD of lumbar spine and left hip joint were measured by dual-energy X-ray absorptiometry. The levels of blood cell counts and HGB were measured and analyzed.The study results showed the WBC, RBC, PLT, and HGB levels of postmenopausal women in the OP group were all higher than those in the non-osteoporosis group. Spearman linear trend analysis and partial correlation analysis demonstrated that BMD was negatively correlated with WBC, RBC, PLT, and HGB in postmenopausal women.Due to the differences between different countries and races, and there are few studies on the association of BMD with peripheral blood cell counts and HGB in Chinese Postmenopausal Women. Therefore, more large sample studies are needed.
骨质疏松症（OP）是一种代谢性骨病，可导致骨髓腔结构改变。骨髓是成人的造血器官。越来越多的证据表明骨髓造血功能与骨形成之间存在密切联系。一些研究表明OP与造血作用有关。然而，这种关系并不明确。本研究旨在评估中国绝经后女性样本中外周血细胞计数（白细胞[WBC]、红细胞[RBC]、血小板[PLT]）、血红蛋白[HGB]和骨密度[BMD]之间的关联。这是一项涉及673例绝经后女性病例的回顾性研究。采用双能X线吸收法测量腰椎和左髋关节的骨密度。对血细胞计数和HGB水平进行测量和分析。研究结果显示，OP组绝经后女性的WBC、RBC、PLT和HGB水平均高于非骨质疏松组。Spearman线性趋势分析和偏相关分析表明，绝经后女性的BMD与WBC、RBC、PLT和HGB呈负相关。由于不同国家和种族之间存在差异，且关于中国绝经后女性BMD与外周血细胞计数和HGB关联的研究较少。因此，需要更多的大样本研究。
