Agarwal Anchal, Bhola Nitin, Kambala Rajanikanth, Borle Rajiv M
Fellow (Oral Oncology), Department of Oral & Maxillofacial Surgery, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, India.
Head of Department and Professor, Department of Oral & Maxillofacial Surgery, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, India.
J Oral Maxillofac Surg. 2019 May;77(5):994-999. doi: 10.1016/j.joms.2019.01.011. Epub 2019 Jan 14.
The purpose was to assess the diagnostic accuracy of touch imprint cytology (TIC) compared with frozen section (FS) analysis as an intraoperative diagnostic tool to assess nodal metastasis in oral squamous cell carcinoma.
We intraoperatively assessed 38 patients undergoing neck dissection for oral squamous cell carcinoma, wherein a total of 248 nodes were sectioned and subjected to TIC and, subsequently, FS analysis and were finally submitted to the gold-standard histopathologic examination. The sensitivities, specificities, positive predictive values (PPVs), and negative predictive values (NPVs) of TIC and FS analysis for the detection of metastasis in the cervical nodes were determined with the corresponding 95% confidence intervals.
TIC had a sensitivity of 62.86%, specificity of 96.24%, PPV of 73.33%, NPV of 94.04%, and accuracy of 91.53% compared with histopathologic results. The sensitivity of FS analysis was 60%, specificity was 98.12%, PPV was 84%, NPV was 93.72%, and accuracy was 92.74% compared with histopathologic examination. These results of TIC were comparable to those of FS analysis.
TIC is a straightforward, quick, and reliable technique. It has a definitive role in being used as an adjunct to FS analysis to increase intraoperative diagnostic accuracy. It can serve as a useful technique in centers that do not have FS availability.
本研究旨在评估触摸印片细胞学检查（TIC）与冰冻切片（FS）分析作为术中诊断工具评估口腔鳞状细胞癌淋巴结转移的诊断准确性。
我们对38例接受口腔鳞状细胞癌颈清扫术的患者进行了术中评估，共对248个淋巴结进行切片，并进行TIC检查，随后进行FS分析，最终进行金标准组织病理学检查。确定了TIC和FS分析检测颈部淋巴结转移的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV），并给出相应的95%置信区间。
与组织病理学结果相比，TIC的敏感性为62.86%，特异性为96.24%，PPV为73.33%，NPV为94.04%，准确性为91.53%。FS分析的敏感性为60%，特异性为98.12%，PPV为84%，NPV为93.72%，准确性为92.74%。TIC的这些结果与FS分析的结果相当。
TIC是一种简单、快速且可靠的技术。它在作为FS分析的辅助手段以提高术中诊断准确性方面具有明确作用。在没有FS设备的中心，它可作为一种有用的技术。
