Gyanchandani Ankita, Shukla Samarth, Vagha Sunita, Acharaya Sourya, Kadu Ravindra P
Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2022 Jul 19;14(7):e27041. doi: 10.7759/cureus.27041. eCollection 2022 Jul.
One of the most common oral malignancies is oral squamous cell carcinoma (OSCC). Although the prevalence of oral cancer varies worldwide, it is generally agreed that the oral cavity is a common anatomical site for cancer, depending primarily on the country (and even particular region in some countries) and gender of the patients. Finding diagnostic markers for OSCC is critical for early diagnosis and personalised treatment of patients. Because they are overexpressed in OSCC relative to normal mucosa, cytokeratins (CKs), intermediate filaments of the cytoskeletons, are possibilities for diagnostic markers of OSCC. CK17 should be targeted as a diagnostic marker for OSCC among the CKs, as multiple other CKs have been linked to the disease. This study aims to assess the immuno-histochemistry expression of CK17 and to investigate whether there is a link between CK17 and OSCC differentiation.
口腔鳞状细胞癌（OSCC）是最常见的口腔恶性肿瘤之一。尽管口腔癌的患病率在全球范围内有所不同，但人们普遍认为口腔是癌症的常见解剖部位，这主要取决于患者所在的国家（甚至某些国家的特定地区）以及性别。寻找OSCC的诊断标志物对于患者的早期诊断和个性化治疗至关重要。细胞角蛋白（CKs）作为细胞骨架的中间丝，由于其在OSCC中相对于正常黏膜过度表达，因此有可能成为OSCC的诊断标志物。在CKs中，CK17应作为OSCC的诊断标志物，因为其他多种CKs已与该疾病相关联。本研究旨在评估CK17的免疫组织化学表达，并调查CK17与OSCC分化之间是否存在关联。
