Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India; Department of Biotechnology, Gauhati University, Guwahati, 781 014, Assam, India.
Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India.
Mech Ageing Dev. 2019 Apr;179:23-35. doi: 10.1016/j.mad.2019.02.001. Epub 2019 Feb 6.
Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut microbiota composition and fecal metabolites of a centenarians group (˜100 years) with young people (25-45 years) of the region with the high centenarian prevalence and the nearby region of low centenarian prevalence to decipher microbial-related longevity signatures. Also, we compared our results with publicly available datasets of similar groups including 125 centenarians from three countries (Italy, Japan, China). Our comparative analysis resulted in higher biodiversity within Ruminococcaceae in centenarians, with respect to younger adults, irrespective of their nationality. We observed bacterial signatures that are common among extremely old people of different nationality. Comparative metabolites profiling identified the fecal metabolic signature of extreme aging in the Indian study population. Our analysis of the co-occurrence network and bimodal distribution of several taxa suggested the establishment of a pervasive change in the gut ecology during extreme aging. Our study might pave the way to develop gut microbiota based biomarkers for healthy aging.
肠道微生物群是可能与健康衰老相关的因素之一。更广泛和具有地理分布的针对百岁老人肠道微生物群的研究有助于确定长寿的共同特征。我们发现了一个具有高百岁老人患病率的内婚印度人群。在这里，我们比较了来自该地区和高百岁老人患病率地区以及低百岁老人患病率地区的一组百岁老人（约 100 岁）与年轻人（25-45 岁）的肠道微生物群落组成和粪便代谢物，以揭示与微生物相关的长寿特征。此外，我们还将我们的结果与包括来自三个国家（意大利、日本和中国）的 125 名百岁老人在内的类似人群的公开可用数据集进行了比较。我们的比较分析表明，与年轻人相比，无论其国籍如何，百岁老人的瘤胃菌科内的生物多样性更高。我们观察到了不同国籍的非常老年人中常见的细菌特征。比较代谢物分析确定了印度研究人群中极端衰老的粪便代谢特征。我们对共生网络和几个分类群的双峰分布的分析表明，在极端衰老期间，肠道生态发生了普遍的变化。我们的研究可能为开发基于肠道微生物群的健康衰老生物标志物铺平道路。
