School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece.
Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Drug Discov Today. 2019 Mar;24(3):737-748. doi: 10.1016/j.drudis.2019.01.020. Epub 2019 Feb 6.
Type 1 diabetes mellitus (T1DM) is a disorder that decimates pancreatic β-cells which produce insulin. Direct pancreatic islet transplantation cannot serve as a widespread therapeutic modality owing to the need for lifelong immunosuppression and donor shortage. Therefore, several encapsulation techniques have been developed to enclose the islets in semipermeable vehicles that will allow oxygen and nutrient input as well as insulin, other metabolites and waste output, while accomplishing immunoisolation. Although encapsulation technology continues to face significant obstacles, recent advances in material science, stem cell biology and immunology potentially serve as pathways to success. This review summarizes the accomplishments of the past 5 years.
1 型糖尿病（T1DM）是一种破坏产生胰岛素的胰腺β细胞的疾病。由于需要终身免疫抑制和供体短缺，直接胰岛移植不能作为一种广泛的治疗方式。因此，已经开发了几种包封技术，将胰岛包裹在半透性载体中，这些载体允许氧气和营养物质的输入以及胰岛素、其他代谢物和废物的输出，同时实现免疫隔离。尽管包封技术仍然面临着重大的障碍，但材料科学、干细胞生物学和免疫学的最新进展可能为成功提供途径。本文综述了过去 5 年的研究进展。
