Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Curr Opin Immunol. 2019 Jun;58:1-8. doi: 10.1016/j.coi.2018.12.004. Epub 2019 Feb 7.
Antigen-presenting cells (APCs) capture and present pathogens to T cells, thus arousing adaptive immune responses geared at the elimination of these invaders. In APCs, pathogens acquired from the extracellular space intersect with MHC class II (MHC-II) molecules in the endolysosomal system, where processing and loading of antigenic peptides occur. The resulting complexes can then be directed to the cell surface for recognition by T cells. To achieve this, the endosomal pathway of APCs must undergo dramatic rearrangements upon pathogen encounter. In this review we discuss recent strides in our understanding of how APCs modulate the organization and function of their endolysosomes to best suit different stages of antigen acquisition, processing and presentation cascade.
抗原提呈细胞 (APCs) 捕获并将病原体呈递给 T 细胞，从而引发针对这些入侵物的适应性免疫反应。在 APC 中，从细胞外空间获得的病原体与内体溶酶体系统中的 MHC Ⅱ类 (MHC-II) 分子相互作用，在此发生抗原肽的加工和加载。然后，这些复合物可以被定向到细胞表面，以便被 T 细胞识别。为了实现这一点，APCs 的内体途径必须在遇到病原体时发生剧烈的重排。在这篇综述中，我们讨论了最近在理解 APC 如何调节内体溶酶体的组织和功能以适应不同阶段的抗原获取、加工和呈递级联方面的进展。
