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一项旨在改变腰椎手术后阿片类药物处方习惯的机构干预措施。

An institutional intervention to modify opioid prescribing practices after lumbar spine surgery.

作者信息

Lovecchio Francis, Stepan Jeffrey G, Premkumar Ajay, Steinhaus Michael E, Sava Maria, Derman Peter, Kim Han Jo, Albert Todd

机构信息

1Hospital for Special Surgery, New York, New York; and.

2Midwest Orthopaedics at Rush, Chicago, Illinois.

出版信息

J Neurosurg Spine. 2019 Feb 5;30(4):483-490. doi: 10.3171/2018.8.SPINE18386. Print 2019 Apr 1.

Abstract

OBJECTIVE

Patients with lumbar spine pathology are at high risk for opioid misuse. Standardizing prescribing practices through an institutional intervention may reduce the overprescribing of opiates, leading to a decrease in the risk for opioid misuse and the number of pills available for diversion. Without quantitative data on the "minimum necessary quantity" of opioids appropriate for postdischarge prescriptions, the optimal method for changing existing prescribing practices is unknown. The purpose of this study was to determine whether mandatory provider education and prescribing guidelines could modify prescriber behavior and lead to a decreased amount of opioids prescribed at hospital discharge following lumbar spine surgery.

METHODS

Qualified staff were required to attend a mandatory educational conference, and a consensus method among the spine service was used to publish qualitative prescribing guidelines. Prescription data for 2479 patients who had undergone lumbar spine surgery were captured and compared based on the timing of surgery. The preintervention group consisted of 1177 patients who had undergone spine surgery in the period before prescriber education and guidelines (March 1, 2016-November 1, 2016). The postintervention group consisted of 1302 patients who had undergone spine surgery after the dissemination of the guidelines (February 1, 2017-October 1, 2017). Surgeries were classified as decompression or fusion procedures. Patients who had undergone surgeries for infection and patients on long-acting opioids were excluded.

RESULTS

For all lumbar spine surgeries (decompression and fusion), the mean amount of opioids prescribed at discharge was lower after the educational program and distribution of prescribing guidelines (629 ± 294 oral morphine equivalent [OME] preintervention vs 490 ± 245 OME postintervention, p < 0.001). The mean number of prescribed pills also decreased (81 ± 26 vs 66 ± 22, p < 0.001). Prescriptions for 81 or more tablets dropped from 65.5% to 25.5%. Tramadol was prescribed more frequently after prescriber education (9.9% vs 18.6%, p < 0.001). Refill rates within 6 weeks were higher after the institutional intervention (7.6% vs 12.4%, p < 0.07).

CONCLUSIONS

Qualitative guidelines and prescriber education are effective in reducing the amount of opioids prescribed at discharge and encouraging the use of weaker opioids. Coupling provider education with prescribing guidelines is likely synergistic in achieving larger reductions. The sustainability of these changes is yet to be determined.

摘要

目的

腰椎疾病患者存在阿片类药物滥用的高风险。通过机构干预规范处方行为可能会减少阿片类药物的过度开具,从而降低阿片类药物滥用风险以及可供转移的药丸数量。由于缺乏关于出院后处方所需阿片类药物“最低必要量”的定量数据,改变现有处方行为的最佳方法尚不清楚。本研究的目的是确定强制性的医生教育和处方指南是否能改变医生行为,并减少腰椎手术后出院时开具的阿片类药物量。

方法

要求合格员工参加强制性教育会议,并采用脊柱服务团队的共识方法发布定性处方指南。收集并比较了2479例接受腰椎手术患者的处方数据,并根据手术时间进行分析。干预前组由1177例在医生教育和指南发布前(2016年3月1日至2016年11月1日)接受脊柱手术的患者组成。干预后组由1302例在指南发布后(2017年2月1日至2017年10月1日)接受脊柱手术的患者组成。手术分为减压或融合手术。排除因感染接受手术的患者和使用长效阿片类药物的患者。

结果

对于所有腰椎手术(减压和融合),在开展教育项目并发布处方指南后,出院时开具的阿片类药物平均量较低(干预前为629±294口服吗啡当量[OME],干预后为490±245 OME,p<0.001)。开具的药丸平均数量也有所减少(81±26 vs 66±22,p<0.001)。开具81片或更多片剂的处方从65.5%降至25.5%。在医生接受教育后,曲马多的处方频率更高(9.9% vs 18.6%,p<0.001)。机构干预后6周内的再填充率更高(7.6% vs 12.4%,p<0.07)。

结论

定性指南和医生教育可有效减少出院时开具的阿片类药物量,并鼓励使用较弱的阿片类药物。将医生教育与处方指南相结合可能会产生协同作用,从而实现更大幅度的减少。这些变化的可持续性尚待确定。

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