[Size Estimation of HLA -Ⅰ class Typed Platelet Apheresis Donor Bank].
作者信息
Xue Min, Pan Qin-Qin, Fan Su, Wang Xiao-Yan, Zhao Fang, Liu Tai-Xiang, Shi Li-Li, Ma Ling, Sheng Jie
机构信息
Jiangsu Province Blood Center，Nanjing 210042，Jiangsu Province, China.E-mail：
Department of HLA, Jiangsu Province People's Hospital, Nanjing 210036, Jiangsu Province，China.
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Feb;27(1):266-271. doi: 10.7534/j.issn.1009-2137.2019.01.043.
OBJECTIVE
To estimate the size of HLA -Ⅰ class typed platelet apheresis donor bank.
METHODS
A total of 16062 blood samples from Chinese Han voluntary unrelated marrow donors in Jiangsu were included in this study. Luminex-SSO was used to detect the HLA -Ⅰ class(A,B locus) antigens. The probability of finding at least one HLA matched unrelated donor was calculated based on the HLA -I class phenotype frequency.
RESULTS
The population genetic data of HLA -Ⅰ class in Jiangsu were obtained, the optinal bans size in HLA typed apheresis plateler donor registry databane hrad been estimated by evaluating the population genetic data of HLA-1 class same donor.
CONCLUSION
The establishment of HLA-1 class typed apheresis platelet donor bank with a total size of 1500 persons is acceptable, which can satisty the patients with phenotype freguency>0.002 to find at least 1 phenotype same donor in 95% probavility.
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