Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Phys Med. 2019 Jan;57:17-24. doi: 10.1016/j.ejmp.2018.12.008. Epub 2018 Dec 19.
To estimate effective dose (E), equivalent organ doses (H) and associated conversion coefficients (CC = E/KAP, CC = H/KAP; KAP = Kerma-area product) in paediatric cardiac interventions, using detailed exposure data from radiation dose structured reports (RDSR). These "RDSR dose estimations" have been compared with estimations performed using the approach currently implemented in the clinic that is based on a simplified assumptions method (SAM).
The Monte Carlo system PCXMC, incorporated into a previously developed framework, was used to calculate E and H for 202 children. The calculations were performed with input values from RDSR, and also using simplified assumptions, including fixed nominal values for the focus-skin distance, collimated beam size, irradiation geometry and patient size (age, weight and height).
Mean H to critical organs were: 5-25 mSv (lungs), 5-8 mSv (breasts) and 5-22 mSv (heart), with the lower and upper end of the doses associated with the neonatal and 15 years group, respectively. The associated mean CC for the different age groups were: 9.4-1.6 mSv/Gycm (lungs), 8.9-0.54 mSv/Gycm (breasts) and 9.3-1.4 mSv/Gycm (heart).
The extension of the concept of a conversion coefficient for H is introduced and CC values for paediatric cardiac interventions divided in age groups are presented. This method of linking the KAP to H is intended for use in epidemiological/cohort studies or in clinics that do not have access to RDSR. Further, the population-averaged conversion coefficients for the critical organs estimated from RDSR, displayed no statistically significant difference compared with the SAM approach.
使用来自辐射剂量结构化报告(RDSR)的详细曝光数据,估算儿科心脏介入中的有效剂量(E)、等效器官剂量(H)和相关转换系数(CC=E/KAP,CC=H/KAP;KAP=比释动能面积乘积)。这些“RDSR 剂量估算”已与使用当前在临床中实施的基于简化假设方法(SAM)的估算方法进行了比较。
使用 PCXMC 蒙特卡罗系统,该系统整合到一个先前开发的框架中,计算了 202 名儿童的 E 和 H。这些计算是使用 RDSR 中的输入值进行的,同时还使用了简化的假设,包括固定的焦点-皮肤距离、准直束大小、照射几何形状和患者大小(年龄、体重和身高)的标称值。
关键器官的平均 H 值为:5-25mSv(肺部)、5-8mSv(乳房)和 5-22mSv(心脏),剂量的下限和上限分别与新生儿和 15 岁组相关。不同年龄组的相关平均 CC 为:9.4-1.6mSv/Gycm(肺部)、8.9-0.54mSv/Gycm(乳房)和 9.3-1.4mSv/Gycm(心脏)。
引入了 H 转换系数的扩展概念,并提出了按年龄分组的儿科心脏介入 CC 值。这种将 KAP 与 H 联系起来的方法旨在用于流行病学/队列研究或无法获得 RDSR 的临床实践中。此外,从 RDSR 估计的关键器官的人群平均转换系数与 SAM 方法相比,没有显示出统计学上的显著差异。