Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station 77843.
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station 77843.
J Dairy Sci. 2019 Apr;102(4):3474-3479. doi: 10.3168/jds.2018-14892. Epub 2019 Feb 7.
Our objectives were to evaluate the clinical efficacy of oral and intranasal administration of a commercial modified-live Salmonella Dublin vaccine in dairy calves and to determine the serologic response associated with these extralabel routes of administration. We conducted a randomized field trial with calves from a New York dairy farm following an outbreak of Salmonella Dublin. A total of 399 Holstein calves were allocated by pen to 3 treatment groups: oral vaccination, intranasal vaccination, and an unvaccinated control group. Administration of the vaccine through oral and intranasal routes did not have a significant effect on pneumonia incidence risk or weight gain; however, calves vaccinated orally and intranasally had lower mortality risk as compared with control calves. Among calves tested using a Salmonella Dublin ELISA, vaccination did not induce an increase in antibody production relative to control calves, indicating that oral and intranasal administration will not hinder diagnosis based on this assay.
我们的目的是评估在犊牛中口服和鼻内给予商业化减毒活都柏林沙门氏菌疫苗的临床疗效，并确定这些标签外给药途径相关的血清学反应。我们对纽约一家奶牛场爆发都柏林沙门氏菌后进行了一项随机现场试验，将 399 头荷斯坦犊牛按围栏分配到 3 个治疗组：口服疫苗接种、鼻内疫苗接种和未接种疫苗的对照组。通过口服和鼻内途径给予疫苗对肺炎发病率风险或体重增加没有显著影响；然而，与对照组犊牛相比，口服和鼻内接种疫苗的犊牛死亡率风险较低。在使用都柏林沙门氏菌 ELISA 检测的犊牛中，疫苗接种并未相对于对照组犊牛增加抗体产生，表明口服和鼻内给药不会干扰基于该检测的诊断。
