Helmy Yosra A, Taha-Abdelaziz Khaled, Hawwas Hanan Abd El-Halim, Ghosh Soumya, AlKafaas Samar Sami, Moawad Mohamed M M, Saied Essa M, Kassem Issmat I, Mawad Asmaa M M
Department of Veterinary Science, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY 40546, USA.
Department of Zoonoses, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Antibiotics (Basel). 2023 Jan 30;12(2):274. doi: 10.3390/antibiotics12020274.
Antimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use of antibiotics in humans and animals has resulted in the emergence of antibiotic-resistant bacteria. The dissemination of these strains and their resistant determinants could endanger antibiotic efficacy. Therefore, there is an urgent need to identify and develop novel strategies to combat antibiotic resistance. This review provides insights into the evolution and the mechanisms of AMR. Additionally, it discusses alternative approaches that might be used to control AMR, including probiotics, prebiotics, antimicrobial peptides, small molecules, organic acids, essential oils, bacteriophage, fecal transplants, and nanoparticles.
抗菌药物耐药性（AMR）是最重要的全球公共卫生问题之一。在人类和动物中不谨慎使用抗生素已导致产生了对抗生素具有耐药性的细菌。这些菌株及其耐药决定因素的传播可能危及抗生素的疗效。因此，迫切需要确定和开发对抗抗生素耐药性的新策略。本综述深入探讨了抗菌药物耐药性的演变和机制。此外，还讨论了可用于控制抗菌药物耐药性的替代方法，包括益生菌、益生元、抗菌肽、小分子、有机酸、精油、噬菌体、粪便移植和纳米颗粒。
