Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia.
J Integr Med. 2019 Mar;17(2):87-92. doi: 10.1016/j.joim.2019.01.009. Epub 2019 Jan 30.
Rising rates of obesity across the globe have been associated with an increase in the use of herbal preparations for weight control. However, the mechanisms of action for these substances are often not known, as is the potential for interaction with other herbal preparations or prescription pharmaceutical drugs. To investigate the reported efficacy and safety of herbal weight loss preparations, we conducted a review of the literature focusing on herbs that are most commonly used in weight loss preparations, specifically, Garcinia cambogia, Camellia sinensis, Hoodia gordonii, Citrus aurantium and Coleus forskohlii. There was no clear evidence that the above herbal preparations would cause sustained long-term weight loss in humans in the long term. Serious illness and even death have occasionally resulted from the use of herbal weight loss preparations. Few clinical trials have been undertaken to evaluate the efficacy and/or safety of herbal weight loss preparations. In addition, potential issues of herb-herb and herb-drug interactions are often not considered. Regulation of these products is much less rigorous than for prescription medications, despite documented cases of associated hepatotoxicity.
全球肥胖率的上升与人们越来越多地使用草药制剂来控制体重有关。然而，这些物质的作用机制通常不为人知，也不知道它们与其他草药制剂或处方药物之间是否存在相互作用的可能性。为了研究报告中提到的草药减肥制剂的疗效和安全性，我们对文献进行了综述，重点关注最常用于减肥制剂的草药，具体来说，包括藤黄果、绿茶、霍多比亚、柑橘和毛喉鞘蕊花。目前没有明确的证据表明上述草药制剂会在长期内导致人类持续的长期体重减轻。严重的疾病甚至死亡偶尔会因使用草药减肥制剂而导致。很少有临床试验来评估草药减肥制剂的疗效和/或安全性。此外，草药-草药和草药-药物相互作用的潜在问题通常也没有被考虑到。尽管有相关的肝毒性病例，但这些产品的监管比处方药要宽松得多。
