评估嗜肺军团菌在伊朗临床样本中的流行率：系统评价和荟萃分析。

Evaluation of the prevalence of Legionella pneumophila in Iranian clinical samples: A systematic review and meta-analysis.

机构信息

Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, IR, Iran.

Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Immunology Department, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Microb Pathog. 2019 Apr;129:93-98. doi: 10.1016/j.micpath.2019.02.008. Epub 2019 Feb 7.

DOI:10.1016/j.micpath.2019.02.008

PMID:30738817

Abstract

BACKGROUND

Legionella pneumophila is the main cause for community-acquired pneumonia especially in hospital environments. In this systematic review and meta-analysis, we evaluated the prevalence of L. pneumophila in clinical samples obtained from Iranian patients.

METHODS

The studies reporting L. pneumophila prevalence in Iranian clinical samples that were published between January 2000 and July 2016 were recruited. Comprehensive Meta-Analysis Software (version 3.3.070) was used for quantitative data analysis. Because of high heterogeneity between the studies according to the Cochrane Q and I statistics, a random-effects model was used for meta-analysis.

RESULTS

Sixteen studies encompassing 1956 subjects were included in the meta-analysis. The overall prevalence of L. pneumophila was 9.6% in clinical samples obtained from the Iranian patients. The age spectrum ranged from 6 months to 80 years old. Dyspnea and cough comprised the most common clinical manifestations. In the subgroup analysis, the prevalence of L. pneumophila was higher in studies with sample size ≤100 (12.9%) in comparison with studies with sample size >100 (8.4%). In addition, the prevalence of L. pneumophila was higher in the years 2009-2016 (9.2%) compared with 2000-2008 (0.7%).

CONCLUSION

L. pneumophila is a major cause of community- and hospital-acquired pneumonia. It is of pivotal importance to implement sensitive and reliable molecular and culture-based techniques to detect and control this infection in healthcare environments.

摘要

背景

嗜肺军团菌是社区获得性肺炎的主要病因，尤其是在医院环境中。在这项系统评价和荟萃分析中，我们评估了嗜肺军团菌在伊朗患者临床样本中的流行率。

方法

我们收集了 2000 年 1 月至 2016 年 7 月期间发表的报告伊朗临床样本中嗜肺军团菌流行率的研究。使用 Comprehensive Meta-Analysis Software（版本 3.3.070）进行定量数据分析。由于根据 Cochrane Q 和 I 统计数据，研究之间存在高度异质性，因此使用随机效应模型进行荟萃分析。

结果

荟萃分析纳入了 16 项研究，共包含 1956 名受试者。从伊朗患者获得的临床样本中，嗜肺军团菌的总体流行率为 9.6%。年龄范围从 6 个月到 80 岁。呼吸困难和咳嗽是最常见的临床表现。在亚组分析中，与样本量>100 的研究相比，样本量≤100 的研究中嗜肺军团菌的流行率更高（12.9% vs. 8.4%）。此外，与 2000-2008 年相比，2009-2016 年嗜肺军团菌的流行率更高（9.2% vs. 0.7%）。