免疫细胞与神经的相互作用及其对镰状细胞病的贡献。

Immune cell neural interactions and their contributions to sickle cell disease.

机构信息

Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

Department of Neurosurgery, University of California San Diego, La Jolla, CA, USA.

出版信息

Neurosci Lett. 2019 Apr 23;699:167-171. doi: 10.1016/j.neulet.2019.02.008. Epub 2019 Feb 7.

DOI:10.1016/j.neulet.2019.02.008

PMID:30738871

Abstract

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain. Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of how the nervous and immune systems interact to contribute to pain and other comorbidities in SCD. Sterile inflammation in the periphery and central nervous system contributes to vascular and neural activation. Cellular and soluble mediators create an inflammatory and neuroinflammatory microenvironment contributing to neurogenic inflammation and acute and chronic pain. In this review we highlight relevant neuro-immune interactions that contribute to the pathobiology of SCD.

摘要

镰状细胞病（SCD）的特征是溶血、炎症和疼痛。疼痛表现的机制很复杂，对于神经系统和免疫系统如何相互作用导致 SCD 中的疼痛和其他合并症，我们的了解还存在很大的差距。外周和中枢神经系统的无菌性炎症导致血管和神经激活。细胞和可溶性介质产生炎症和神经炎症微环境，导致神经原性炎症和急性及慢性疼痛。在这篇综述中，我们强调了相关的神经免疫相互作用，这些相互作用有助于 SCD 的病理生物学。