综合方法治疗镰状细胞病疼痛：临床前和临床证据。
Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence.
机构信息
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Hematology/Oncology, Department of Medicine, University of California, Irvine and Southern California Institute for Research and Education, VA Medical Center, Long Beach, CA, United States.
出版信息
Complement Ther Med. 2020 Jun;51:102394. doi: 10.1016/j.ctim.2020.102394. Epub 2020 May 11.
Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain treatment in SCD; however, continued use is associated with several adverse effects. Integrative approaches to treating pain in SCD are increasingly being explored to prevent the side effects associated with opioids. In this review, we highlight the mechanisms of pain in SCD and describe mechanism-based integrative approaches for treating pain.
镰状细胞病（SCD）是一种遗传性疾病，其特征为溶血、终末器官损伤、炎症和疼痛。镰状细胞病的一个独特特征是由于血管阻塞危机反复发作且不可预测的急性疼痛发作。许多患者还会终生患有慢性疼痛。阿片类药物是 SCD 疼痛治疗的主要方法；然而，持续使用会引起多种不良反应。目前越来越多地探索综合方法来治疗 SCD 疼痛，以预防与阿片类药物相关的副作用。在这篇综述中，我们强调了 SCD 疼痛的机制，并描述了基于机制的综合方法来治疗疼痛。
Zotero 插件