Cuerpo Académico de Biotecnología Agroalimentaria, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Av. Universidad km 1, Rancho Universitario, C.P. 43600, Tulancingo de Bravo, Hidalgo, Mexico.
Biotechnol Lett. 2019 May;41(4-5):453-469. doi: 10.1007/s10529-018-02635-5. Epub 2019 Feb 9.
The encapsulation of bacteriocins from lactic acid bacteria has involved several methods to protect them from unfavourable environmental conditions and incompatibilities. This review encompasses different methods for the encapsulation of bacteriocins and their applications in both food and pharmaceutical fields. Based on the bibliometric analysis of publications from well-reputed journals including different available patents during the period from 1996 to 2017, 135 articles and 60 patents were collected. Continent-wise contributions to the bacteriocins encapsulation research were carried out by America (52%), Asia (29%) and Europe (19%); with the United States of America, Brazil, Thailand and Italy the countries with major contributions. Till date, different methods proposed for encapsulation have been (i) Film coatings (50%), (ii) Liposomes (23%), (iii) Nanofibers (22%) and (iv) Nanoparticles (4%). Bacteriocins encapsulation methods frequently carried out in food protection (70%); while in the pharmaceutical field, 30% of the research was conducted on multi drug resistant therapy.
乳酸菌细菌素的包封涉及了几种方法来保护它们免受不利的环境条件和不兼容性的影响。本综述涵盖了细菌素包封的不同方法及其在食品和制药领域的应用。根据对 1996 年至 2017 年期间知名期刊上的出版物进行的文献计量分析，包括不同的现有专利，共收集了 135 篇文章和 60 项专利。从大陆范围来看，对细菌素包封研究的贡献来自于美国（52%）、亚洲（29%）和欧洲（19%）；美国、巴西、泰国和意大利是贡献最大的国家。迄今为止，已经提出了不同的包封方法，包括（i）薄膜包衣（50%）、（ii）脂质体（23%）、（iii）纳米纤维（22%）和（iv）纳米颗粒（4%）。细菌素包封方法在食品保护中经常使用（70%）；而在制药领域，有 30%的研究用于多药耐药性治疗。
