特发性肉芽肿性乳腺炎患者的人类白细胞抗原 I 类和 II 类。

Human leukocyte antigens class I and II in patients with idiopathic granulomatous mastitis.

机构信息

Saglik Bilimleri University, Faculty of Medicine, Konya Education and Research Hospital, Department of General Surgery, Yeni Meram Cad, Number: 97, Konya, Turkey.

出版信息

Am J Surg. 2019 Sep;218(3):605-608. doi: 10.1016/j.amjsurg.2019.01.038. Epub 2019 Jan 31.

DOI:10.1016/j.amjsurg.2019.01.038

PMID:30739742

Abstract

BACKGROUND

To determine the distribution of human leukocyte antigens (HLA) in patients with idiopathic granulomatous mastitis (IGM).

METHODS

The study included 48 patients diagnosed with IGM and 50 controls consisting of healthy donor candidates.

RESULTS

The frequencies of HLA-A10, HLA-A2403, HLA-B18 and HLA-DR17 antigens were significantly higher in the patient group than control group (p = 0.012, p = 0.012, p = 0.0001 and p = 0.005, respectively). However, the frequencies of HLA-A29, HLA-B14 and HLA-DR1 were lower in the patient group than control group (p = 0.027, p = 0.013 and p = 0.015, respectively). When patients without/with relapse were compared, there was a significant difference in HLA-A3 (p = 0.048) and HLA-A32 (p = 0.011). Also, the patients with relapse and control group were compared in respects of HLA-A10 (p = 0.0006), HLA-A24 (p = 0.035), HLA-A32 (p = 0.011), HLA-B18 (p = 0.035), HLA-B103 (p = 0.035) and HLA-DR*17 (p = 0.006).

CONCLUSION

These findings may help to explain etiopathogenesis but still, further studies on this subject with more patients in different geographic regions are needed.

摘要

背景

为了确定特发性肉芽肿性乳腺炎（IGM）患者人类白细胞抗原（HLA）的分布。

方法

本研究纳入了 48 名确诊为 IGM 的患者和 50 名健康供者作为对照组。

结果

与对照组相比，患者组 HLA-A10、HLA-A2403、HLA-B18 和 HLA-DR17 抗原的频率显著升高（p=0.012、p=0.012、p=0.0001 和 p=0.005）。然而，患者组 HLA-A29、HLA-B14 和 HLA-DR1 的频率低于对照组（p=0.027、p=0.013 和 p=0.015）。当比较无复发和有复发的患者时，HLA-A3（p=0.048）和 HLA-A32（p=0.011）存在显著差异。此外，在 HLA-A10（p=0.0006）、HLA-A24（p=0.035）、HLA-A32（p=0.011）、HLA-B18（p=0.035）、HLA-B103（p=0.035）和 HLA-DR*17（p=0.006）方面，有复发的患者与对照组之间也存在显著差异。