Bhatta Sushama, Singh Samir, Gautam Santosh, Osti Bidur Prasad
Department of Pathology, KIST Medical College, Imadol, Lalitpur, Nepal.
Department of Biochemistry, KIST Medical College, Imadol, Lalitpur, Nepal.
J Nepal Health Res Counc. 2019 Jan 28;16(41):392-395.
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia and associated with long term macrovascular and microvascular complications. Platelet parameters such as mean platelet volume and platelet count are indicators of thrombotic potential. These parameters have been reported to be increased in diabetic patients, leading to increased risk of vascular complications. The objective of this study was to determine mean platelet volume and platelet count in patients with Type 2 Diabetes mellitus, impaired fasting glucose and non -diabetic controls, and compare mean platelet volume and platelet count between the three groups.
A hospital based cross-sectional observational study was conducted at KIST Medical College Teaching Hospital from February to May 2018. A total of 300 participants were included in the study which were grouped into Group 1,2 and 3 based on fasting blood glucose level as non -diabetic controls, impaired fasting glucose and Type 2 Diabetes mellitus respectively with 100 subjects each. Platelet count and mean platelet volume were compared between the three groups. Analysis of variance with post hoc Tukey test and Pearson correlation coefficient were used for statistical evaluation. Data were expressed as mean ± standard deviation. A p value <0.05 was considered as statistically significant.
Mean platelet volume was significantly higher in diabetic and impaired fasting glucose group (7.40 ± 0.77 fl and 6.62 ± 0.58 fl), respectively as compared to non diabetic group (6.06 ± 0.41 fl) (p<0.001). There was no significant difference in the platelet count between the three groups (p=0.869). Significant correlation was seen between rising fasting blood sugar and mean platelet volume (r =0.559; p<0.001), while no correlation existed between platelet count and fasting blood sugar level (r =0.037; p =0.526).
Mean platelet volume is increased in patients with type 2 diabetes mellitus and impaired fasting glucose. This is a simple and cost effective test to predict vascular complications in type 2 diabetes mellitus.
糖尿病是一种以高血糖为特征的慢性代谢紊乱疾病，与长期的大血管和微血管并发症相关。血小板参数如平均血小板体积和血小板计数是血栓形成潜力的指标。据报道，糖尿病患者的这些参数会升高，导致血管并发症风险增加。本研究的目的是测定2型糖尿病患者、空腹血糖受损患者和非糖尿病对照组的平均血小板体积和血小板计数，并比较三组之间的平均血小板体积和血小板计数。
2018年2月至5月在KIST医学院教学医院进行了一项基于医院的横断面观察性研究。共有300名参与者纳入研究，根据空腹血糖水平分为1组、2组和3组，分别为非糖尿病对照组、空腹血糖受损组和2型糖尿病组，每组100名受试者。比较三组之间的血小板计数和平均血小板体积。采用方差分析及事后Tukey检验和Pearson相关系数进行统计学评估。数据以平均值±标准差表示。p值<0.05被认为具有统计学意义。
与非糖尿病组（6.06±0.41fl）相比，糖尿病组和空腹血糖受损组的平均血小板体积显著更高（分别为7.40±0.77fl和6.62±0.58fl）（p<0.001）。三组之间的血小板计数无显著差异（p = 0.869）。空腹血糖升高与平均血小板体积之间存在显著相关性（r = 0.559；p<0.001），而血小板计数与空腹血糖水平之间无相关性（r = 0.037；p = 0.526）。
2型糖尿病患者和空腹血糖受损患者的平均血小板体积增加。这是一种预测2型糖尿病血管并发症的简单且经济有效的检测方法。
