Biadgo Belete, Melku Mulugeta, Abebe Solomon Mekonnen, Abebe Molla
School of Biomedical and Laboratory Sciences, Department of Clinical Chemistry, University of Gondar, Gondar, Ethiopia.
School of Biomedical and Laboratory Sciences, Department of Hematology and Immunohematology, University of Gondar, Gondar, Ethiopia.
Diabetes Metab Syndr Obes. 2016 Mar 17;9:91-9. doi: 10.2147/DMSO.S97563. eCollection 2016.
Diabetes mellitus is (DM) a global public health problem and a complex disease characterized by chronic hyperglycemia that leads to long-term macrovascular and microvascular complications. Recent studies have reported the role of hematological indices in contributing to the vascular injury in diabetic patients. Thus, the aim of this study was to determine hematological indices and their correlation with fasting blood glucose level and anthropometric measurement in type 2 DM patients in comparison with healthy controls.
A comparative cross-sectional study was conducted at the chronic illness clinic of Gondar University Hospital from February to April 2015. A total of 296 participants (148 cases and 148 healthy controls) were selected using systematic random sampling technique. Data were collected using a pretested structured questionnaire. Fasting blood glucose levels and hematological indices were determined by using Bio Systems A25 and Sysmex-KX 21N analyzers, respectively. Independent sample t-test, Mann-Whitney U-test, and correlation statistics were used. A P-value <0.05 was considered as statistically significant.
There was significant difference in red blood cell distribution width (47.3±2.6 fL vs 45.2±3 fL) between diabetic patients and controls. Total white blood cells in 10(3)/µL (6.59±1.42 vs 5.56±1.38), absolute lymphocyte count in 10(3)/µL (2.60±0.70 vs 2.04±0.63), and absolute neutrophil count in 10(3)/µL (3.57±1.46 vs 3.11±1.04) increased significantly in diabetic patients compared with controls, respectively. Among platelet indices, mean platelet volume (10.4±1.1 fL vs 9.9±1.1 fL) and platelet distribution width (14.5±2.1 fL vs 13.4 ±2.1 fL) were found to be significantly increased in the diabetic patients (P<0.05). Anthropometric measurements significantly correlated with white blood cell and platelet indices.
The study showed statistically significant difference in some hematological parameters of diabetic patients compared to controls. Thus, hematological indices could be useful indicators of vascular complication and glycemic control in type 2 DM patients.
糖尿病是一个全球性的公共卫生问题，是一种以慢性高血糖为特征的复杂疾病，可导致长期的大血管和微血管并发症。最近的研究报道了血液学指标在糖尿病患者血管损伤中的作用。因此，本研究的目的是确定2型糖尿病患者的血液学指标及其与空腹血糖水平和人体测量指标的相关性，并与健康对照进行比较。
2015年2月至4月在贡德尔大学医院慢性病门诊进行了一项比较性横断面研究。采用系统随机抽样技术共选取296名参与者（148例患者和148名健康对照）。使用预先测试的结构化问卷收集数据。分别使用Bio Systems A25和Sysmex-KX 21N分析仪测定空腹血糖水平和血液学指标。采用独立样本t检验、曼-惠特尼U检验和相关性统计分析。P值<0.05被认为具有统计学意义。
糖尿病患者与对照组之间的红细胞分布宽度存在显著差异（47.3±2.6 fL对45.2±3 fL）。糖尿病患者每微升10³个白细胞总数（6.59±1.42对5.56±1.38）、每微升10³个绝对淋巴细胞计数（2.60±0.70对2.04±0.63）和每微升10³个绝对中性粒细胞计数（3.57±1.46对3.11±1.04）均分别显著高于对照组。在血小板指标中，糖尿病患者的平均血小板体积（10.4±1.1 fL对9.9±1.1 fL）和血小板分布宽度（14.5±2.1 fL对13.4±2.1 fL）显著增加（P<0.05）。人体测量指标与白细胞和血小板指标显著相关。
该研究表明，糖尿病患者的一些血液学参数与对照组相比有统计学显著差异。因此，血液学指标可能是2型糖尿病患者血管并发症和血糖控制的有用指标。
