由二氢青蒿酸合成青蒿二烯。
Synthesis of amorpha-4,11-diene from dihydroartemisinic acid.
作者信息
Schwertz Geoffrey, Zanetti Andrea, Nascimento de Oliveira Marllon, Gomez Fernandez Mario Andrès, Dioury Fabienne, Cossy Janine, Amara Zacharias
机构信息
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231, ESPCI ParisTech/CNRS/PSL Research University, Paris Cedex 05, France.
Equipe de Chimie Moléculaire, Laboratoire GBCM, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, 2 rue Conté, 75003, Paris, France.
出版信息
Tetrahedron. 2019 Feb 8;75(6):743-748. doi: 10.1016/j.tet.2018.12.050.
Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography.
紫穗槐二烯是一种参与抗疟药物青蒿素生物合成的天然产物。本文报道了一种从市售二氢青蒿酸出发，简便的四步合成紫穗槐二烯的方法。目标分子通过四步反应，仅经过一次柱层析，以多克规模分离得到，总收率为85%。
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