Nishigaki F, Yoda K, Takahashi T, Takimoto K, Watanabe T, Shimokawa H, Hirano T, Kataoka Y, Yoshiki T
Department of Central Laboratories, Sapporo City General Hospital.
Hokkaido Igaku Zasshi. 1988 Nov;63(6):859-63.
It is important to examine the presence of preformed antibodies in hemodialysis patients before renal transplantation, because it causes the graft rejection in organ transplantation. In the 239 hemodialysis patients we analysed 3 preformed antibodies divided TW, BW and BC. Sensitized rate (TW+, BW+ and BC+) was 0% at no blood transfusions (BT), 9.3% at 1-5 BT and 28.9% at 6 more BT. The number of blood transfusions increased the sensitized rate (TW). Sensitized rate (BW+, BC+) was 6.2% at no BT, 9.3% at 1-5BT and 12.0% at 6 more BT, while sensitized rate (BC+) was 33.3% at no BT, 26.7% at 1-5BT and 14.5% at 6 more BT. There was no correlation between the number of blood transfusions and the sensitized rate (BW+, BC+). At one year after the first check, 69.2% of TW positive patients was converted to TW negative and 53.8% of BW positive patients was converted to BW negative each. Further studies of the preformed antibodies are required to assess the clinical course of long surviving patients.
在肾移植前检查血液透析患者体内预先形成的抗体的存在情况很重要，因为它会导致器官移植中的移植物排斥反应。在239名血液透析患者中，我们分析了3种预先形成的抗体，分为TW、BW和BC。在未输血（BT）的情况下，致敏率（TW +、BW +和BC +）为0%，在输血1 - 5次时为9.3%，在输血6次及以上时为28.9%。输血次数增加了致敏率（TW）。在未输血时，致敏率（BW +、BC +）为6.2%，输血1 - 5次时为9.3%，输血6次及以上时为12.0%，而致敏率（BC +）在未输血时为33.3%，输血1 - 5次时为26.7%，输血6次及以上时为14.5%。输血次数与致敏率（BW +、BC +）之间没有相关性。在首次检查一年后，TW阳性患者中有69.2%转为TW阴性，BW阳性患者中有53.8%转为BW阴性。需要对预先形成的抗体进行进一步研究，以评估长期存活患者的临床病程。
