Vaishampayan Ulka, Shi Dongping, Abdulfatah Eman, Aoun Hussein, Wynberg Jason
Department of Oncology, Wayne State University/Karmanos Cancer Institute, Detroit, MI, USA.
Department of Pathology, Wayne State University/Karmanos Cancer Institute, Detroit, MI, USA.
Urol Case Rep. 2019 Jan 28;23:103-105. doi: 10.1016/j.eucr.2019.01.018. eCollection 2019 Mar.
Pathologic complete response is an exceptionally rare occurrence in prostate cancer, especially in the setting of poorly differentiated cancer, with high risk and poor prognostic features. Patient reviewed and signed an informed consent. The case details were collected. Patient had PSA of 52.6 ng/dl and Gleason score 5 + 5 = 10 prostate adenocarcinoma with focal signet ring cell pattern. Genomic testing revealed pathogenic p53 and SPOP mutations. The patient received androgen deprivation therapy and six cycles of docetaxel. His PSA declined to undetectable, and radical prostatectomy (RP) showed no evidence of malignancy. The patient has discontinued all therapy and continues in remission 12 months after surgery.
病理完全缓解在前列腺癌中极为罕见，尤其是在分化差的癌症情况下，这类癌症具有高风险和不良预后特征。患者已审阅并签署知情同意书。收集了病例详细信息。患者前列腺特异性抗原（PSA）为52.6 ng/dl， Gleason评分5 + 5 = 10，患有局灶印戒细胞型前列腺腺癌。基因检测显示p53和SPOP基因发生致病性突变。该患者接受了雄激素剥夺治疗和六个周期的多西他赛治疗。其PSA降至检测不到的水平，根治性前列腺切除术（RP）未发现恶性肿瘤迹象。患者已停止所有治疗，术后12个月仍处于缓解状态。
