Borgström B, Bolme P
Department of Pediatrics, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
Horm Res. 1988;30(2-3):98-100. doi: 10.1159/000181037.
Growth and growth hormone (GH) were investigated every year in 24 children after allogeneic bone marrow transplantation (BMT) for severe aplastic anemia (SAA) or leukemia. Conditioning included total body irradiation (TBI) in all cases of leukemia. The young leukemic children grew poorly. At 4 years after BMT, the mean standard deviation score for attained height had decreased from 0 to -1.73. GH deficiency was diagnosed with provocation tests. Three years after BMT, 10/18 children had a subnormal response. Ten children were further investigated with 24-hour GH profiles. Children with SAA had normal growth and GH levels. TBI seemed to be the major factor responsible for impaired growth.
对24名因严重再生障碍性贫血（SAA）或白血病接受异基因骨髓移植（BMT）的儿童每年进行生长情况及生长激素（GH）的研究。所有白血病病例的预处理均包括全身照射（TBI）。年幼的白血病儿童生长不良。骨髓移植后4年，达到身高的平均标准差评分从0降至-1.73。通过激发试验诊断出生长激素缺乏。骨髓移植后3年，18名儿童中有10名反应异常。对10名儿童进行了24小时生长激素谱的进一步研究。再生障碍性贫血儿童的生长和生长激素水平正常。全身照射似乎是导致生长受损的主要因素。
