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Management of hard-to-heal diabetic foot ulcers: local use of autologous leucocytes, platelets and fibrin multi-layered patches (LeucoPatch).难愈合糖尿病足溃疡的管理：自体白细胞、血小板和纤维蛋白多层贴片（白细胞贴片）的局部应用。
Ann Transl Med. 2018 Dec;6(Suppl 2):S126. doi: 10.21037/atm.2018.12.44.
2
LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial.LeucoPatch 系统治疗英国、丹麦和瑞典的难愈性糖尿病足溃疡：一项观察者设盲、随机对照试验。
Lancet Diabetes Endocrinol. 2018 Nov;6(11):870-878. doi: 10.1016/S2213-8587(18)30240-7. Epub 2018 Sep 19.
3
The LeucoPatch® system in the management of hard-to-heal diabetic foot ulcers: study protocol for a randomised controlled trial.LeucoPatch®系统用于治疗难愈合的糖尿病足溃疡：一项随机对照试验的研究方案
Trials. 2017 Oct 10;18(1):469. doi: 10.1186/s13063-017-2216-9.
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Use of an autologous leucocyte and platelet-rich fibrin patch on hard-to-heal DFUs: a pilot study.自体富白细胞和富血小板纤维蛋白贴片用于难愈合糖尿病足溃疡的初步研究。
J Wound Care. 2015 Apr;24(4):172-4, 176-8. doi: 10.12968/jowc.2015.24.4.172.
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Bilayered bioengineered skin substitute (Apligraf): a review of its use in the treatment of venous leg ulcers and diabetic foot ulcers.双层生物工程皮肤替代物（Apligraf）：其用于治疗下肢静脉溃疡和糖尿病足溃疡的综述
BioDrugs. 2002;16(6):439-55. doi: 10.2165/00063030-200216060-00005.
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A pilot study to evaluate the safety and clinical performance of Leucopatch, an autologous, additive-free, platelet-rich fibrin for the treatment of recalcitrant chronic wounds.一项评估Leucopatch安全性和临床性能的试点研究，Leucopatch是一种用于治疗顽固性慢性伤口的自体、无添加剂、富含血小板的纤维蛋白。
Int J Low Extrem Wounds. 2011 Dec;10(4):218-23. doi: 10.1177/1534734611426755. Epub 2011 Oct 18.
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The phagocytic fitness of leucopatches may impact the healing of chronic wounds.白色斑块的吞噬适应性可能会影响慢性伤口的愈合。
Clin Exp Immunol. 2016 Jun;184(3):368-77. doi: 10.1111/cei.12773. Epub 2016 Mar 23.
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Two-step autologous grafting using HYAFF scaffolds in treating difficult diabetic foot ulcers: results of a multicenter, randomized controlled clinical trial with long-term follow-up.使用HYAFF支架的两步自体移植治疗难愈性糖尿病足溃疡：一项长期随访的多中心随机对照临床试验结果
Int J Low Extrem Wounds. 2011 Jun;10(2):80-5. doi: 10.1177/1534734611409371.
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Hyperbaric oxygen therapy as adjunctive treatment for diabetic foot ulcers.高压氧疗法作为糖尿病足溃疡的辅助治疗方法。
Int J Low Extrem Wounds. 2013 Jun;12(2):152-7. doi: 10.1177/1534734613486154. Epub 2013 May 9.
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Hard-to-heal diabetic foot ulcers treated using negatively charged polystyrene microspheres: a prospective case series.使用带负电荷的聚苯乙烯微球治疗难愈合的糖尿病足溃疡：一项前瞻性病例系列研究。
J Wound Care. 2019 Feb 2;28(2):104-109. doi: 10.12968/jowc.2019.28.2.104.

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Improving Microcirculation With Nerve Decompression: The Missing Link in Treatment of Diabetic Neuropathy and Diabetic Foot Ulcer.通过神经减压改善微循环：糖尿病神经病变和糖尿病足溃疡治疗中缺失的环节
Int Wound J. 2025 Apr;22(4):e70198. doi: 10.1111/iwj.70198.
2
Diabetic Wound-Healing Science.糖尿病创面愈合科学。
Medicina (Kaunas). 2021 Oct 8;57(10):1072. doi: 10.3390/medicina57101072.

本文引用的文献

1
Cortical disruption is the most reliable and accurate plain radiographic sign in the diagnosis of diabetic foot osteomyelitis.皮质破坏是糖尿病足骨髓炎诊断中最可靠、最准确的X线平片征象。
Diabet Med. 2019 Feb;36(2):258-259. doi: 10.1111/dme.13824.
2
LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial.LeucoPatch 系统治疗英国、丹麦和瑞典的难愈性糖尿病足溃疡：一项观察者设盲、随机对照试验。
Lancet Diabetes Endocrinol. 2018 Nov;6(11):870-878. doi: 10.1016/S2213-8587(18)30240-7. Epub 2018 Sep 19.
3
Ultrasound-assisted debridement of neuroischaemic diabetic foot ulcers, clinical and microbiological effects: a case series.超声辅助清创治疗神经缺血性糖尿病足溃疡的临床及微生物学效果：病例系列研究
J Wound Care. 2018 May 2;27(5):278-286. doi: 10.12968/jowc.2018.27.5.278.
4
Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report).富含白细胞血小板纤维蛋白（L-PRF）在糖尿病足溃疡合并骨髓炎中的应用（三例临床病例报告）
Diseases. 2018 Apr 24;6(2):30. doi: 10.3390/diseases6020030.
5
Multicenter, randomized controlled, observer-blinded study of a nitric oxide generating treatment in foot ulcers of patients with diabetes-ProNOx1 study.糖尿病患者足部溃疡一氧化氮生成治疗的多中心、随机对照、观察者盲法研究——ProNOx1研究
Wound Repair Regen. 2018 Mar;26(2):228-237. doi: 10.1111/wrr.12630. Epub 2018 Jul 17.
6
Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial.蔗糖八硫酸酯敷料与对照敷料治疗神经缺血性糖尿病足溃疡（Explorer）的国际多中心双盲随机对照试验。
Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196. doi: 10.1016/S2213-8587(17)30438-2. Epub 2017 Dec 20.
7
Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells.自体干细胞治疗糖尿病足溃疡的荟萃分析。
Stem Cell Res Ther. 2017 Oct 16;8(1):228. doi: 10.1186/s13287-017-0683-2.
8
The LeucoPatch® system in the management of hard-to-heal diabetic foot ulcers: study protocol for a randomised controlled trial.LeucoPatch®系统用于治疗难愈合的糖尿病足溃疡：一项随机对照试验的研究方案
Trials. 2017 Oct 10;18(1):469. doi: 10.1186/s13063-017-2216-9.
9
Efficacy and Safety of Hyperbaric Oxygen Therapy Used in Patients With Diabetic Foot: A Meta-analysis of Randomized Clinical Trials.高压氧疗法用于糖尿病足患者的疗效与安全性：一项随机临床试验的荟萃分析
Clin Ther. 2017 Oct;39(10):2088-2094.e2. doi: 10.1016/j.clinthera.2017.08.014. Epub 2017 Sep 19.
10
Diabetic Foot Ulcers and Their Recurrence.糖尿病足溃疡及其复发
N Engl J Med. 2017 Jun 15;376(24):2367-2375. doi: 10.1056/NEJMra1615439.

Management of hard-to-heal diabetic foot ulcers: local use of autologous leucocytes, platelets and fibrin multi-layered patches (LeucoPatch).

作者信息

Álvaro-Afonso Francisco Javier, Lázaro-Martínez Jose Luis, García-Álvarez Yolanda, Papanas Nikolaos

机构信息

Diabetic Foot Unit, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.

出版信息

Ann Transl Med. 2018 Dec;6(Suppl 2):S126. doi: 10.21037/atm.2018.12.44.

DOI:10.21037/atm.2018.12.44
PMID:30740447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330603/
Abstract
摘要