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Initiation of renal replacement therapy in patients with sepsis: more to it than meets the eye.脓毒症患者肾脏替代治疗的启动：其中的门道比表面所见更多。
Ann Transl Med. 2018 Dec;6(Suppl 2):S130. doi: 10.21037/atm.2018.12.36.
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Continuous Renal Replacement Therapy in Pediatric Severe Sepsis: A Propensity Score-Matched Prospective Multicenter Cohort Study in the PICU.儿科严重脓毒症的连续性肾脏替代治疗：儿科重症监护病房的倾向评分匹配前瞻性多中心队列研究。
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Clinical variables associated with poor outcome from sepsis-associated acute kidney injury and the relationship with timing of initiation of renal replacement therapy.与脓毒症相关性急性肾损伤不良预后相关的临床变量及其与开始肾脏替代治疗时机的关系。
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Effect of the intensity of continuous renal replacement therapy in patients with sepsis and acute kidney injury: a single-center randomized clinical trial.连续性肾脏替代治疗强度对脓毒症合并急性肾损伤患者的影响：一项单中心随机临床试验。
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Renal replacement therapy in sepsis-induced acute renal failure.脓毒症诱导的急性肾衰竭的肾脏替代治疗
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Early initiation renal replacement therapy for fluid management to reduce central venous pressure is more conducive to renal function recovery in patients with acute kidney injury.早期开始肾脏替代治疗以进行液体管理来降低中心静脉压，更有利于急性肾损伤患者的肾功能恢复。
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Continuous renal replacement therapy in children with severe sepsis and multiorgan dysfunction - A pilot study on timing of initiation.连续性肾脏替代疗法用于重症脓毒症和多器官功能障碍患儿——一项关于开始时机的初步研究
Indian J Crit Care Med. 2015 Oct;19(10):613-7. doi: 10.4103/0972-5229.167044.
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[Continuous renal replacement therapy and negative fluid balance improves renal function and prognosis of patients with acute kidney injury in sepsis].持续肾脏替代治疗与负液体平衡改善脓毒症急性肾损伤患者肾功能及预后
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 May;27(5):321-6. doi: 10.3760/cma.j.issn.2095-4352.2015.05.001.

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Urinary Liver-Type Fatty Acid Binding Protein (L-FABP) in Early Detection and Outcome Prediction of Sepsis-Associated Acute Kidney Injury.尿肝型脂肪酸结合蛋白（L-FABP）在脓毒症相关急性肾损伤的早期检测及预后预测中的作用
Arch Acad Emerg Med. 2025 Jan 13;13(1):e26. doi: 10.22037/aaemj.v13i1.2525. eCollection 2025.
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Lactate-enhanced-qSOFA (LqSOFA) score is superior to the other four rapid scoring tools in predicting in-hospital mortality rate of the sepsis patients.乳酸增强型qSOFA（LqSOFA）评分在预测脓毒症患者的院内死亡率方面优于其他四种快速评分工具。
Ann Transl Med. 2020 Aug;8(16):1013. doi: 10.21037/atm-20-5410.
3
Initiation of renal replacement therapy in patients with septic acute kidney injury: right timing or right patient?脓毒症急性肾损伤患者开始肾脏替代治疗：时机恰当还是患者恰当？
Ann Transl Med. 2019 Oct;7(20):598. doi: 10.21037/atm.2019.09.78.
4
Preemptive renal replacement therapy in post-cardiotomy cardiogenic shock patients: a historically controlled cohort study.心脏术后心源性休克患者的早期肾脏替代治疗：一项历史对照队列研究。
Ann Transl Med. 2019 Oct;7(20):534. doi: 10.21037/atm.2019.09.140.

本文引用的文献

1
Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis.急性肾损伤合并脓毒症患者肾脏替代治疗时机。
N Engl J Med. 2018 Oct 11;379(15):1431-1442. doi: 10.1056/NEJMoa1803213.
2
Global epidemiology and outcomes of acute kidney injury.全球急性肾损伤的流行病学和结局。
Nat Rev Nephrol. 2018 Oct;14(10):607-625. doi: 10.1038/s41581-018-0052-0.
3
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.急性呼吸窘迫综合征亚表型与辛伐他汀反应的差异：一项随机对照试验的二次分析。
Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2.
4
Biomarkers for prediction of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis.用于急性肾损伤肾替代治疗预测的生物标志物：系统评价和荟萃分析。
Intensive Care Med. 2018 Mar;44(3):323-336. doi: 10.1007/s00134-018-5126-8. Epub 2018 Mar 14.
5
Timing of Renal Support and Outcome of Septic Shock and Acute Respiratory Distress Syndrome. A Post Hoc Analysis of the AKIKI Randomized Clinical Trial.肾脏支持时机与感染性休克和急性呼吸窘迫综合征结局的关系。AKIKI 随机临床试验的事后分析。
Am J Respir Crit Care Med. 2018 Jul 1;198(1):58-66. doi: 10.1164/rccm.201706-1255OC.
6
Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.根据血液基因组内型对脓毒症患者进行分类：一项前瞻性队列研究。
Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.
7
The immunopathology of sepsis and potential therapeutic targets.脓毒症的免疫病理学及潜在治疗靶点
Nat Rev Immunol. 2017 Jul;17(7):407-420. doi: 10.1038/nri.2017.36. Epub 2017 Apr 24.
8
Acute kidney injury in sepsis.脓毒症相关性急性肾损伤。
Intensive Care Med. 2017 Jun;43(6):816-828. doi: 10.1007/s00134-017-4755-7. Epub 2017 Mar 31.
9
The use of enrichment to reduce statistically indeterminate or negative trials in critical care.在重症监护中利用富集设计减少统计学上不确定或阴性的试验。
Anaesthesia. 2017 May;72(5):560-565. doi: 10.1111/anae.13870. Epub 2017 Mar 20.
10
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.拯救脓毒症运动：脓毒症与脓毒性休克管理国际指南：2016版
Crit Care Med. 2017 Mar;45(3):486-552. doi: 10.1097/CCM.0000000000002255.

Initiation of renal replacement therapy in patients with sepsis: more to it than meets the eye.

作者信息

Uhel Fabrice, Peters-Sengers Hessel, van der Poll Tom

机构信息

Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Ann Transl Med. 2018 Dec;6(Suppl 2):S130. doi: 10.21037/atm.2018.12.36.

DOI:10.21037/atm.2018.12.36
PMID:30740451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330630/
Abstract
摘要