主要痴呆综合征中的日间过度嗜睡。
Excessive Daytime Sleepiness in Major Dementia Syndromes.
机构信息
1 Mayo Clinic, Rochester, MN, USA.
2 Mayo Clinic, Jacksonville, FL, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2019 Jun;34(4):261-264. doi: 10.1177/1533317519828046. Epub 2019 Feb 10.
Abstract
There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P < .05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P < .01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.
摘要
尚未对阿尔茨海默病痴呆（AD）、路易体痴呆（DLB）和行为变异额颞叶痴呆（bvFTD）患者的日间过度嗜睡（EDS）进行比较。我们确定了符合这些疾病标准且完成了 Epworth 嗜睡量表（ESS）的轻度痴呆患者。该样本包括 17 名 bvFTD、111 名 AD 和 31 名 DLB。ESS 评分≥10 被认为异常，并与 EDS 一致。经年龄和性别作为协变量进行分析后发现，DLB 的平均 ESS 评分高于其他组（DLB 13.9 [5]，bvFTD 9.6 [8]，AD 8.8 [5]，P <.05）。ESS 评分≥10 在 DLB 中比 bvFTD 或 AD 更常见（DLB 81%比 bvFTD 47%比 AD 45%，P <.01）。在轻度痴呆患者中，DLB 的 EDS 最大，而 bvFTD 和 AD 的 EDS 相对较低。
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