Feng Ziqian, Wang Jiayu, Xu Lisi, Wu Jiajing, Li Hongyi, Wang Ziqi, Duan Mingjun
MOE Key Lab for Neuroinformation, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Department of Geriatrics, The Fourth People's Hospital of Chengdu, Chengdu, China.
J Alzheimers Dis Rep. 2024 Jun 18;8(1):935-944. doi: 10.3233/ADR-230101. eCollection 2024.
Excessive daytime sleepiness (EDS) and caudate nucleus volume alterations have been linked to Alzheimer's disease (AD), but their relationship remains unclear under the context of subjective cognitive decline (SCD).
This study aimed to investigate the relationship between EDS and caudate nucleus volume in patients with SCD.
The volume of entire brain was measured in 170 patients with SCD, including 37 patients with EDS and 133 non-EDS, from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Participants underwent a comprehensive assessment battery, including neuropsychological and clinical evaluations, blood tests, genetic analysis for 4, and structural MRI scans analyzed using the fully automated segmentation tool, volBrain.
Patients with EDS had significantly increased volume in the total and left caudate nucleus compared to non-EDS. The most significant cognitive behavioral factor associated with caudate nucleus volume in the EDS was the Auditory Verbal Learning Test-recognition.
These findings suggest that EDS may be associated with alterations in caudate nucleus volume, particularly in the left hemisphere, in the context of SCD. Further research is necessary to understand the underlying mechanisms of this relationship and its implications for clinical management.
日间过度嗜睡（EDS）和尾状核体积改变与阿尔茨海默病（AD）有关，但在主观认知下降（SCD）的背景下，它们之间的关系仍不清楚。
本研究旨在调查SCD患者中EDS与尾状核体积之间的关系。
对来自中国认知下降纵向研究（SILCODE）的170例SCD患者进行全脑体积测量，其中包括37例EDS患者和133例非EDS患者。参与者接受了全面的评估，包括神经心理学和临床评估、血液检查、4项基因分析，以及使用全自动分割工具volBrain分析的结构MRI扫描。
与非EDS患者相比，EDS患者的总尾状核和左侧尾状核体积显著增加。在EDS患者中，与尾状核体积相关的最显著认知行为因素是听觉词语学习测试-识别。
这些发现表明，在SCD背景下，EDS可能与尾状核体积改变有关，尤其是在左半球。有必要进一步研究以了解这种关系的潜在机制及其对临床管理的影响。
