a Departamento de Fisiologia, Laboratório de Metabolismo Celular , Universidade Federal do Paraná , Curitiba , Brazil.
b Departamento de Biologia Celular , Universidade Federal do Paraná , Curitiba , Brazil.
Nutr Cancer. 2019;71(1):111-117. doi: 10.1080/01635581.2018.1557219. Epub 2019 Feb 9.
Capsaicin (trans-8-methyl-n-vanillyl-6-nonenamide) is the main pungent component found in hot peppers.
In this study, we investigated the effect of capsaicin treatment on tumor growth and the metabolic indicators of cachexia in Walker 256 tumor-bearing rats.
Male Wistar rats were inoculated subcutaneously in the right flank with 1 ml of a sterile suspension of 3 × 10 Walker tumor cells. The treated groups received capsaicin intraperitoneal 5 mg/kg body weight for 13 days.
The tumor weight on Day 14 in the non-treated group was 18 g. The rats also had a body weight loss, hypoglycemia, hyperlactacidemia, hypertriacylglycerolemia, and a depletion in glycogen storage. Treatment with capsaicin decreased tumor growth by 49% and a reversal of triacylglycerol serum. We also found a 32% reduction in tumor cell proliferation ex vivo. Lactate serum concentrations and body weight were lower but did not reach control levels.
The treatment with capsaicin reduces tumor growth and cellular proliferation along with increased apoptosis and partial cachexia reversal.
本研究旨在探讨辣椒素处理对 Walker 256 肿瘤荷瘤大鼠肿瘤生长和恶病质代谢指标的影响。
雄性 Wistar 大鼠右侧肋腹皮下接种 1ml 无菌 3×10 Walker 肿瘤细胞悬浮液。处理组大鼠腹腔内给予辣椒素 5mg/kg 体重，共 13 天。
未处理组第 14 天肿瘤重量为 18g。大鼠还出现体重减轻、低血糖、高乳酸血症、高三酰甘油血症和糖原储存减少。辣椒素治疗使肿瘤生长减少 49%，并逆转了三酰甘油血症。我们还发现体外肿瘤细胞增殖减少了 32%。乳酸血清浓度和体重较低，但未达到对照水平。
辣椒素治疗可减少肿瘤生长和细胞增殖，同时增加细胞凋亡并部分逆转恶病质。
