a Department of Reproductive Medicine , Bahceci Fulya IVF Centre , Istanbul , Turkey.
b Embryology Laboratory , British Cyprus IVF Hospital , Nicosia , USA.
Syst Biol Reprod Med. 2019 Jun;65(3):250-257. doi: 10.1080/19396368.2019.1573275. Epub 2019 Feb 11.
The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Age, body mass index, fertilization rates were similar within the groups. However, the number of previous ART trials was found to be higher ( < 0.05) in the study group. Also, the number of retrieved oocytes and M2 oocytes were found to be significantly lower in patients with endometriosis ( < 0.01). The duration of the first cell cycle (ECC1) and S2 (the time between t3 and t4) displayed significant distortions compared with embryos in the control group. All other analyzed early morphokinetic parameters (t2, t3, t4, t5, t6, t7, t8) and duration of events (VP, cc2a, ECC2, ECC3, S3) showed similar values between study and control groups, respectively. In the light of these findings, it is apparent that endometriosis predominantly affects the duration of the early morphokinetic events and cell cycles.
本研究旨在通过比较从患有临床确诊子宫内膜异位症的女性和因输卵管因素不孕的女性中获得的胚胎的形态动力学发育，评估子宫内膜异位症对早期胚胎发育的可能影响。共评估了 82 个周期/患者，其中 53 个周期患有子宫内膜异位症，29 个周期患有输卵管因素不孕。对 439 个胚胎的胚胎形态动力学进行了评分。组内的年龄、体重指数和受精率相似。然而，研究组的既往 ART 试验次数较多（<0.05）。此外，患有子宫内膜异位症的患者的获卵数和 M2 卵母细胞数明显较低（<0.01）。与对照组相比，第一细胞周期（ECC1）和 S2（t3 和 t4 之间的时间）的持续时间显示出明显的扭曲。所有其他分析的早期形态动力学参数（t2、t3、t4、t5、t6、t7、t8）和事件持续时间（VP、cc2a、ECC2、ECC3、S3）在研究组和对照组之间分别显示出相似的值。根据这些发现，很明显，子宫内膜异位症主要影响早期形态动力学事件和细胞周期的持续时间。
