Akarsu Suleyman, Gode Funda, Isik Ahmet Zeki, Celenk Hayriye, Tamer Ferda Burcu, Erkilinc Selcuk
a Medikalpark İzmir Hospital IVF Center , İzmir , Turkey and.
b Tepecik Education and Research Hospital , İzmir , Turkey.
Gynecol Endocrinol. 2017 Sep;33(9):733-736. doi: 10.1080/09513590.2017.1312327. Epub 2017 Apr 17.
The aim of this study is to evaluate the impact of ovarian reserve and age of women on early morphokinetic parameters of embryos with a time-lapse monitoring system. In total, 197 infertile couples with poor ovarian reserve (Group 1, n = 41), normal ovarian reserve (Group 2, n = 59), or polycystic ovaries (Group 3, n = 97) were included. The time from insemination to the following events were analyzed: pronuclear fading (Pnf) and cleavage to 2, 3, 4 and 5 cells. The optimal ranges for morphokinetic parameters of t5, s2 and cc2 in each group were also evaluated. In total, 1144 embryos were evaluated. Morphokinetic parameters did not differ statistically between the groups. Data were analyzed according to different age groups (20-30, 30-40, >40). The morphokinetic parameters did not differ statistically in Group 1 and 3. In Group 2, the times from insemination to tPnf, t2, t3, t4 were significantly shorter in the younger age group than the older age group (p < 0.05). The percentages of optimal embryos, according to t5, s2 and cc2, did not differ statistically between the groups. In conclusion, ovarian reserve did not seem to affect the morphokinetic parameters of embryos.
本研究的目的是利用延时监测系统评估女性的卵巢储备和年龄对胚胎早期形态动力学参数的影响。总共纳入了197对卵巢储备功能不良的不孕夫妇（第1组，n = 41）、卵巢储备功能正常的不孕夫妇（第2组，n = 59）或多囊卵巢不孕夫妇（第3组，n = 97）。分析了从授精到以下事件的时间：原核消失（Pnf）以及卵裂至2、3、4和5细胞。还评估了每组中t5、s2和cc2形态动力学参数的最佳范围。总共评估了1144个胚胎。各组之间的形态动力学参数在统计学上无差异。数据根据不同年龄组（20 - 30岁、30 - 40岁、>40岁）进行分析。第1组和第3组的形态动力学参数在统计学上无差异。在第2组中，年轻年龄组从授精到tPnf、t2、t3、t4的时间明显短于年长年龄组（p < 0.05）。根据t5、s2和cc2，各组之间最佳胚胎的百分比在统计学上无差异。总之，卵巢储备似乎并未影响胚胎的形态动力学参数。
