Otolaryngology Institute, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, 200233, China.
Sci Rep. 2019 Feb 11;9(1):1743. doi: 10.1038/s41598-019-38582-y.
We designed a prospective study to evaluate changes in tinnitus after vestibular schwannoma (VS) surgery. Subjects included 41 patients who were diagnosed with a VS and underwent translabyrinthine microsurgery (TLM) between January 2015 and May 2016. All patients underwent related examinations and were asked to answer the Tinnitus Handicap Inventory (THI) scale and a visual analog scale (VAS) of tinnitus severity both pre- and postoperatively. Of the 41 patients, 31 (75.6%) suffered from tinnitus before surgery. Microsurgery was associated with an overall decrease in tinnitus (p < 0.001). There was a significant improvement in THI and VAS scores after surgery (p = 0.001 and p = 0.005, respectively). The decrease in THI scores in the low-frequency group was significantly larger than that of the mid- and high-frequency groups after surgery (p = 0.034 and p = 0.001, respectively). The loudness of tinnitus decreased significantly after surgery (p = 0.031). Tinnitus in patients with VS improved after TLM. Patients with mid-/high-frequency tinnitus and louder tinnitus preoperatively seemed to have a worse prognosis than those with low-frequency and quieter tinnitus.
我们设计了一项前瞻性研究,以评估前庭神经鞘瘤(VS)手术后耳鸣的变化。研究对象包括 41 例被诊断为 VS 并于 2015 年 1 月至 2016 年 5 月期间接受经迷路显微手术(TLM)的患者。所有患者均接受了相关检查,并要求在术前和术后回答耳鸣残疾量表(THI)和耳鸣严重程度的视觉模拟量表(VAS)。在这 41 例患者中,有 31 例(75.6%)在手术前患有耳鸣。显微手术与耳鸣总体减轻相关(p<0.001)。术后 THI 和 VAS 评分均显著改善(p=0.001 和 p=0.005)。术后低频组的 THI 评分下降明显大于中高频组(p=0.034 和 p=0.001)。手术后耳鸣的响度显著降低(p=0.031)。VS 患者的耳鸣在 TLM 后有所改善。术前中频/高频耳鸣和更响亮的耳鸣患者似乎比低频和更安静的耳鸣患者预后更差。