Unit of Epileptology, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, Milano, Italy.
Unit of Epileptology, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, Milano, Italy.
Neurobiol Dis. 2019 May;125:190-197. doi: 10.1016/j.nbd.2019.02.007. Epub 2019 Feb 8.
Focal seizures are triggered by the pathological synchronization of a functionally altered group of neurons. In vivo and in vitro results in rodents and single unit studies in humans suggest that seizure can be initiated by increased activity in interneuronal networks. We review here the data derived from in vitro perparations to describe the function of GABAergic network in different phases of focal seizures. The data demonstrate that GABA-mediated synchronization of interneuronal activity has an active role in shaping focal seizure dynamics.
局灶性癫痫发作是由功能改变的神经元群病理性同步引起的。在啮齿动物的体内和体外以及人类的单细胞研究结果表明，癫痫发作可以由中间神经元网络活性增加引发。我们在此回顾了来自体外研究的结果，以描述 GABA 能网络在局灶性癫痫发作不同阶段的功能。这些数据表明，GABA 介导的中间神经元活动同步在塑造局灶性癫痫发作动力学方面具有积极作用。
