• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

自体间充质干细胞应用于复发性髌骨脱位软骨缺损:一例报告。

Autologous mesenchymal stem cell application for cartilage defect in recurrent patellar dislocation: A case report.

作者信息

Lubis Andri Maruli Tua, Panjaitan Troydimas, Hoo Charles

机构信息

Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia.

Mitra Keluarga Kelapa Gading, Jakarta, Indonesia.

出版信息

Int J Surg Case Rep. 2019;55:183-186. doi: 10.1016/j.ijscr.2019.01.031. Epub 2019 Jan 31.

DOI:10.1016/j.ijscr.2019.01.031
PMID:30743221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6369132/
Abstract

INTRODUCTION

Recurrent patellar dislocation can lead to articular cartilage injury. We report a 21-year old male with left patella instability and articular cartilage defect.

PRESENTATION OF CASE

A 21-year-old male presented with left patellar instability and pain. Knee range of motion (ROM) was limited when patella was dislocated (0-20°). The J-sign positive, patellar apprehension test was positive, with medial patella elasticity/patellar glide >2 quadrants. The Q angle, in the 90° flexed knee position was still normal. The plain radiograph imaging showed no abnormality. Insall-Salvati index was 1.12. The patient was diagnosed with recurrent patellar dislocation and cartilage lesion of the left knee, and was treated with combining Fulkerson osteotomy with the lateral retinacular release and percutaneous medial plication, followed by microfracture procedure and MSCs implantation.

DISCUSSION

Recurrent patellar dislocation is uncommon problem while cartilage lesions following recurrent patellar dislocations are quite common, but still no consensus on the management.

CONCLUSION

Combination of Fulkerson osteotomy with the lateral retinacular release and percutaneous medial plication was effective in treating chronic patellar instability. The microfracture procedure and MSCs implantation was safe and could improve the cartilage regeneration in patients with articular cartilage defect due to recurrent patellar dislocation.

摘要

引言

复发性髌骨脱位可导致关节软骨损伤。我们报告一例21岁男性,患有左髌骨不稳定及关节软骨缺损。

病例介绍

一名21岁男性因左髌骨不稳定及疼痛就诊。髌骨脱位时膝关节活动范围(ROM)受限(0-20°)。J征阳性,髌骨恐惧试验阳性,髌骨内侧弹性/髌骨滑动>2个象限。屈膝90°位时Q角仍正常。X线平片未见异常。Insall-Salvati指数为1.12。该患者被诊断为左膝复发性髌骨脱位及软骨损伤,采用Fulkerson截骨术联合外侧支持带松解及经皮内侧皱襞成形术治疗,随后进行微骨折手术及间充质干细胞植入。

讨论

复发性髌骨脱位并不常见,而复发性髌骨脱位后的软骨损伤却相当常见,但在治疗方法上仍未达成共识。

结论

Fulkerson截骨术联合外侧支持带松解及经皮内侧皱襞成形术治疗慢性髌骨不稳定有效。微骨折手术及间充质干细胞植入安全,可促进因复发性髌骨脱位导致关节软骨缺损患者的软骨再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/d16fc71eb95b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/366bb0a8f881/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/c3660d5283f2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/e0059a461867/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/d16fc71eb95b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/366bb0a8f881/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/c3660d5283f2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/e0059a461867/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b29/6369132/d16fc71eb95b/gr4.jpg

相似文献

1
Autologous mesenchymal stem cell application for cartilage defect in recurrent patellar dislocation: A case report.自体间充质干细胞应用于复发性髌骨脱位软骨缺损:一例报告。
Int J Surg Case Rep. 2019;55:183-186. doi: 10.1016/j.ijscr.2019.01.031. Epub 2019 Jan 31.
2
Modified Elmslie-Trillat Procedure for Recurrent Dislocation of the Patella.改良Elmslie-Trillat手术治疗复发性髌骨脱位
J Knee Surg. 2017 Jun;30(5):493-500. doi: 10.1055/s-0036-1593363. Epub 2016 Oct 3.
3
Arthroscopic lateral retinacular release, medial retinacular plication and partial medial tibial tubercle transfer for recurrent patellar dislocation.关节镜下外侧支持带松解、内侧支持带紧缩及部分胫骨结节内移治疗复发性髌骨脱位。
Int J Surg. 2017 Aug;44:43-48. doi: 10.1016/j.ijsu.2017.06.027. Epub 2017 Jun 15.
4
Modified Fulkerson osteotomy in recurrent patellofemoral dislocations.复发性髌股关节脱位的改良Fulkerson截骨术
Acta Orthop Traumatol Turc. 2010;44(1):27-35. doi: 10.3944/AOTT.2010.2143.
5
Management of patellar instability using knee arthroscopy and combined anterior and medial tibial tubercle transfer: A case report and literature review.使用膝关节镜检查及联合胫骨结节前内侧转移术治疗髌骨不稳定:一例报告及文献综述
Int J Surg Case Rep. 2024 Jun;119:109734. doi: 10.1016/j.ijscr.2024.109734. Epub 2024 May 8.
6
[Arthroscopic medial patellofemoral ligament reconstruction combined with lateral retinacular release for recurrent patellar dislocation].关节镜下内侧髌股韧带重建联合外侧支持带松解治疗复发性髌骨脱位
Zhongguo Gu Shang. 2015 Jul;28(7):599-602.
7
[Recurrent dislocation of the patella--arthroscopic therapy].[复发性髌骨脱位——关节镜治疗]
Acta Chir Orthop Traumatol Cech. 2002;69(4):254-8.
8
[Treatment of Extensive Chondral Defects of the Patella after Patellar Dislocation].[髌骨脱位后髌骨大面积软骨缺损的治疗]
Acta Chir Orthop Traumatol Cech. 2017;84(6):441-447.
9
Recurrent Patellar Instabilty Culminating in a Vertically Rotated and a Locked Patellar Dislocation - A Rare Entity.复发性髌骨不稳定最终导致垂直旋转和锁定性髌骨脱位——一种罕见情况。
J Orthop Case Rep. 2016 Apr-Jun;6(2):95-97. doi: 10.13107/jocr.2250-0685.456.
10
Anatomic Risk Factors for Focal Cartilage Lesions in the Patella and Trochlea: A Case-Control Study.髌股和滑车关节局灶性软骨病变的解剖学危险因素:病例对照研究。
Am J Sports Med. 2019 Aug;47(10):2444-2453. doi: 10.1177/0363546519859320. Epub 2019 Jul 9.

引用本文的文献

1
Articular Cartilage Damage Worsens from First-time to Recurrent Patellar Dislocation-A Longitudinal Magnetic Resonance Imaging Study.从首次到复发性髌骨脱位,关节软骨损伤加重——一项纵向磁共振成像研究
Arthrosc Sports Med Rehabil. 2021 Dec 8;4(2):e343-e347. doi: 10.1016/j.asmr.2021.10.006. eCollection 2022 Apr.
2
Decreasing Thickness of Partial Lateral Trochlear Cartilage in Patients with Patellar Instability.髌股关节不稳患者部分外侧滑车软骨厚度变薄。
Orthop Surg. 2021 Jun;13(4):1196-1204. doi: 10.1111/os.12971. Epub 2021 May 4.
3
MicroRNA-126 promotes proliferation, migration, invasion and endothelial differentiation while inhibits apoptosis and osteogenic differentiation of bone marrow-derived mesenchymal stem cells.

本文引用的文献

1
The SCARE Statement: Consensus-based surgical case report guidelines.SCARE 声明:基于共识的外科手术病例报告指南。
Int J Surg. 2016 Oct;34:180-186. doi: 10.1016/j.ijsu.2016.08.014. Epub 2016 Sep 7.
2
Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up.注射用培养骨髓间充质干细胞治疗伴有软骨缺损的内翻膝骨关节炎行胫骨高位截骨术后:一项前瞻性、随机对照临床试验,随访 2 年。
Arthroscopy. 2013 Dec;29(12):2020-8. doi: 10.1016/j.arthro.2013.09.074.
3
Therapeutic effects of mesenchymal stem cells and hyaluronic Acid injection on osteochondral defects in rabbits' knees.
微小 RNA-126 促进骨髓间充质干细胞的增殖、迁移、侵袭和内皮分化,同时抑制其凋亡和成骨分化。
Cell Cycle. 2020 Sep;19(17):2119-2138. doi: 10.1080/15384101.2020.1788258. Epub 2020 Aug 13.
间充质干细胞与透明质酸注射对兔膝关节骨软骨缺损的治疗作用
Knee Surg Relat Res. 2012 Sep;24(3):164-72. doi: 10.5792/ksrr.2012.24.3.164. Epub 2012 Sep 3.
4
Isolation and cultivation of mesenchymal stem cells from iliac crest bone marrow for further cartilage defect management.从髂嵴骨髓中分离培养间充质干细胞以进一步治疗软骨缺损
Acta Med Indones. 2011 Jul;43(3):178-84.
5
Operative versus non-operative management of patellar dislocation. A meta-analysis.手术与非手术治疗髌骨脱位的比较:一项荟萃分析。
Knee Surg Sports Traumatol Arthrosc. 2011 Jun;19(6):988-98. doi: 10.1007/s00167-010-1355-2. Epub 2011 Jan 14.
6
Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study.自体骨髓间充质干细胞与自体软骨细胞移植的比较:一项观察性队列研究。
Am J Sports Med. 2010 Jun;38(6):1110-6. doi: 10.1177/0363546509359067. Epub 2010 Apr 14.
7
Patellar instability.髌骨不稳定
J Bone Joint Surg Am. 2009 Sep;91(9):2264-75.
8
The efficacy of intra-articular hyaluronan injection after the microfracture technique for the treatment of articular cartilage lesions.微骨折技术治疗关节软骨损伤后关节腔内注射透明质酸的疗效。
Am J Sports Med. 2009 Apr;37(4):720-6. doi: 10.1177/0363546508328415. Epub 2009 Feb 9.
9
The management of recurrent patellar dislocation.复发性髌骨脱位的治疗
Orthop Clin North Am. 2008 Jul;39(3):313-27, vi. doi: 10.1016/j.ocl.2008.03.005.
10
Modifications of the Fulkerson osteotomy: a pilot study assessment of a novel technique of dynamic intraoperative determination of the adequacy of tubercle transfer.富尔克森截骨术的改良:一项关于术中动态确定结节转移充分性的新技术的初步研究评估
Iowa Orthop J. 2007;27:61-4.