Kalambokis George, Milionis Haralampos J
a Lecturer of Internal Medicine, Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10, Ioannina, Greece.
b Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10, Ioannina, Greece.
Expert Rev Endocrinol Metab. 2009 May;4(3):251-261. doi: 10.1586/eem.09.6.
Endocrine diseases, such as diabetes mellitus and thyroid dysfunction, have been rarely associated with increased serum transaminase activity. The association of Addison's disease with abnormal liver function tests has received less attention. Addison's disease as a part of autoimmune polyglandular syndrome-1 may be associated with autoimmune hepatitis. Addison's disease may also coexist with celiac disease, an autoimmune disorder commonly associated with hypertransaminasemia. On the other hand, a number of case reports have suggested hypertransaminasemia to be one of the few diagnostic clues to the underlying adrenal insufficiency, allowing the introduction of steroid replacement and obviation of a potential adrenal crisis. We performed a thorough literature review on the prevalence and pathogenesis of hypertransaminasemia as a feature of Addison's disease in an attempt to highlight an as yet under-recognized association.
内分泌疾病，如糖尿病和甲状腺功能障碍，很少与血清转氨酶活性升高相关。艾迪生病与肝功能检查异常之间的关联较少受到关注。作为自身免疫性多腺体综合征1型一部分的艾迪生病可能与自身免疫性肝炎有关。艾迪生病也可能与乳糜泻共存，乳糜泻是一种通常与高转氨酶血症相关的自身免疫性疾病。另一方面，一些病例报告表明，高转氨酶血症是潜在肾上腺功能不全的少数诊断线索之一，从而可以开始使用类固醇替代治疗并避免潜在的肾上腺危象。我们对作为艾迪生病特征的高转氨酶血症的患病率和发病机制进行了全面的文献综述，以突出这一尚未得到充分认识的关联。
