a Guangdong Key Laboratory of New Dosage Forms of Drugs , Guangdong Pharmaceutical University , Guangzhou , China.
b College of pharmacy , Guangdong Pharmaceutical University , Guangzhou , China.
Drug Dev Ind Pharm. 2019 Jun;45(6):905-913. doi: 10.1080/03639045.2019.1576723. Epub 2019 Mar 20.
The aim of this study was to determine the effect of varying excipient content on the formation and physical properties of 3 D printed tablets. Fifteen different excipient preparations were formed into tablets with radii of 5 mm and thickness of 2 mm, using binder jetting (BJ). The tablets were analyzed by assessing visual and microstructural appearance, friability, hardness, and disintegration time. We found that filling agents with high water solubility (e.g. D-sucrose), binding agents with a high viscosity in solution (e.g. polyethylene glycol 4000) and moistening agent with higher water content can increase the bonding strength and hardness of the 3 D printed tablets and prolonged their disintegration time. This work has demonstrated that the type of excipient and its concentration affects the properties of the 3 D printed tablet. This article may be used as a guide for elucidation of the effects of using conventional tablet excipients in the field of 3 D printed pharmaceuticals. The present work should enable the identification of excipients that satisfy requirements, reduce analysis time, and improve efficiency.
本研究旨在确定赋形剂含量变化对 3D 打印片剂形成和物理性质的影响。使用粘结剂喷射（BJ）技术，将 15 种不同的赋形剂制备成半径为 5mm、厚度为 2mm 的片剂。通过评估片剂的外观和微观结构、脆性、硬度和崩解时间来分析片剂。我们发现，高水溶性的填充剂（如 D-蔗糖）、高溶液粘度的结合剂（如聚乙二醇 4000）和高含水量的润湿剂可以提高 3D 打印片剂的粘结强度和硬度，并延长其崩解时间。这项工作表明，赋形剂的类型及其浓度会影响 3D 打印片剂的性质。本文可作为阐明传统片剂赋形剂在 3D 打印制药领域应用的影响的指南。本工作有望确定满足要求的赋形剂，减少分析时间，提高效率。
