Heparanase in health and disease: The neglected housekeeper of the cell?
作者信息
Shu Jun, Santulli Gaetano
机构信息
Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.
Department of Medicine and Department of Molecular Pharmacology, The Wilf Family Cardiovascular Research Institute, New York, NY, USA; "The Norman Fleischer Institute for Diabetes and Metabolism", Einstein-Sinai Diabetes Research Center, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY, USA; Department of Biomedical Advanced Sciences, "Federico II" University, Naples, Italy.
出版信息
Atherosclerosis. 2019 Apr;283:124-126. doi: 10.1016/j.atherosclerosis.2019.01.017. Epub 2019 Jan 25.
Abstract
摘要
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本文引用的文献
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Dual roles of heparanase in human carotid plaque calcification.硫酸乙酰肝素酶在人颈动脉斑块钙化中的双重作用。
Atherosclerosis. 2019 Apr;283:127-136. doi: 10.1016/j.atherosclerosis.2018.12.027. Epub 2019 Jan 5.
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The heparanase inhibitor PG545 is a potent anti-lymphoma drug: Mode of action.硫酸乙酰肝素酶抑制剂 PG545 是一种强效的抗淋巴瘤药物：作用机制。
Matrix Biol. 2019 Apr;77:58-72. doi: 10.1016/j.matbio.2018.08.005. Epub 2018 Aug 7.
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Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.肝素酶-1 和肝素酶-2 在癌症进展中的相反功能。
Trends Biochem Sci. 2018 Jan;43(1):18-31. doi: 10.1016/j.tibs.2017.10.007. Epub 2017 Nov 20.
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Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.化疗诱导含有乙酰肝素酶的外泌体分泌，降解细胞外基质，并影响肿瘤和宿主细胞的行为。
Matrix Biol. 2018 Jan;65:104-118. doi: 10.1016/j.matbio.2017.09.001. Epub 2017 Sep 6.
5
Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.乙酰肝素酶：在细胞存活、细胞外基质重塑和肾脏疾病发展中的作用。
Nat Rev Nephrol. 2017 Apr;13(4):201-212. doi: 10.1038/nrneph.2017.6. Epub 2017 Feb 6.
6
Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination.硫酸乙酰肝素支持锥体神经元兴奋性、突触可塑性和情境辨别。
Cereb Cortex. 2017 Feb 1;27(2):903-918. doi: 10.1093/cercor/bhx003.
7
Heparanase is required for activation and function of macrophages.硫酸乙酰肝素酶是巨噬细胞激活和发挥功能所必需的。
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7808-E7817. doi: 10.1073/pnas.1611380113. Epub 2016 Nov 14.
8
Structural characterization of human heparanase reveals insights into substrate recognition.人乙酰肝素酶的结构表征揭示了对底物识别的见解。
Nat Struct Mol Biol. 2015 Dec;22(12):1016-22. doi: 10.1038/nsmb.3136. Epub 2015 Nov 16.
9
Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca(2+) channels.肝素/硫酸乙酰肝素与神经元 L 型（Cav1.2）电压依赖性钙（Ca2+）通道结合并调节其功能。
Exp Neurol. 2015 Dec;274(Pt B):156-65. doi: 10.1016/j.expneurol.2015.08.006. Epub 2015 Aug 10.
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Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy.乙酰肝素酶通过促进自噬增强肿瘤生长和化疗耐药性。
Cancer Res. 2015 Sep 15;75(18):3946-57. doi: 10.1158/0008-5472.CAN-15-0037. Epub 2015 Aug 6.
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