Huang Mingzhu, Wang Bianbian, Li Xiaopeng, Fu Chongluo, Wang Changhe, Kang Xinjiang
School of Life Sciences, Liaocheng University, Liaocheng, China.
Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Front Neurosci. 2019 Jan 28;13:28. doi: 10.3389/fnins.2019.00028. eCollection 2019.
α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson's disease. However, the physiological roles of α-Syn remain poorly understood. Recent studies have indicated a critical role of α-Syn in the sensing and generation of membrane curvature during vesicular exocytosis and endocytosis. It has been known to modulate the assembly of SNARE complex during exocytosis including vesicle docking, priming and fusion steps. Growing evidence suggests that α-Syn also plays critical roles in the endocytosis of synaptic vesicles. It also modulates the availability of releasable vesicles by promoting synaptic vesicles clustering. Here, we provide an overview of recent progresses in understanding the function of α-Syn in the regulation of exocytosis, endocytosis, and vesicle recycling under physiological and pathological conditions.
α-突触核蛋白（α-Syn）是一种在突触前富集的蛋白质，参与帕金森病的发病机制。然而，α-Syn的生理作用仍知之甚少。最近的研究表明，α-Syn在囊泡胞吐和内吞过程中对膜曲率的感知和产生起着关键作用。已知它在胞吐过程中调节SNARE复合体的组装，包括囊泡对接、启动和融合步骤。越来越多的证据表明，α-Syn在突触小泡的内吞作用中也起着关键作用。它还通过促进突触小泡聚集来调节可释放囊泡的可用性。在这里，我们概述了在生理和病理条件下，对α-Syn在调节胞吐、内吞和囊泡循环功能方面的最新研究进展。
