Sertogullarindan Bunyamin, Komuroglu Ahmet Ufuk, Ucler Rifki, Gunbatar Hulya, Sunnetcioglu Aysel, Cokluk Erdem
Department of Pulmonary Medicine, Medical Faculty, Katip Celebi University, Izmir, Turkey.
Vocational School of Health Services, Yuzuncu Yil University, Van, Turkey.
Ann Thorac Med. 2019 Jan-Mar;14(1):63-68. doi: 10.4103/atm.ATM_52_18.
Obstructive sleep apnea (OSA) is a common sleep problem, in which patients are at increased risk for metabolic and cardiovascular problems, including metabolic syndrome, diabetes mellitus (DM), and dyslipidemia. Betatrophin is a novel protein that regulates fatty acid and triglyceride (TG) metabolism and is related to obesity and metabolic abnormalities, including metabolic syndrome, DM, and dyslipidemia. Although OSA and betatrophin share common abnormalities, their relationship has not been investigated.
The aim of this study is to investigate the relationships among betatrophin, OSA, and the serum lipid profile.
Ninety consecutive patients with suspected OSA underwent polysomnography (PSG) to confirm OSA. Plasma betatrophin, leptin, adiponectin, and the full lipid profile were analyzed. The patients were categorized as OSA or control based on the apnea-hypopnea index (AHI).
About 61% of patients had OSA, and 39% had normal PSG. The levels of betatrophin, leptin, and adiponectin were higher in patients with OSA (256.59 ± 29.35, 374.20 ± 37.93, and 17.86 ± 2.63 μg/mL, respectively) compared to the controls (141.86 ± 26.20, 205.53 ± 14.75, and 7.52 ± 1.02 μg/mL, respectively). Betatrophin levels were correlated with the AHI, leptin ( = 0.413, = 0.002, r = 0.782, = 0.000). TG levels were significantly higher, and high-density lipoprotein cholesterol (HDL-C) levels were lower, in OSA patients compared to controls (244 ± 20.33 vs. 138 ± 14.89, and 37.21 ± 1.26 vs. 43.78 ± 1.62, respectively). The TG level was correlated with betatrophin ( = 0.353, = 0.013). Multiple regression analysis showed that the AHI, leptin, and arousals were independent predictors of betatrophin level (B = 1.70 = 0.046 95%, B = 0.56 < 0.005, and B = 1, 2, = 0.003, respectively).
Our results suggest a complex relationship between OSA, betatrophin, TG, and HDL, as well as other adipokines. Our results require further investigation to assess this complex association and re-evaluate previous related studies.
阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠问题，患者出现代谢和心血管问题的风险增加，包括代谢综合征、糖尿病（DM）和血脂异常。β-促细胞生成素是一种调节脂肪酸和甘油三酯（TG）代谢的新型蛋白质，与肥胖和代谢异常有关，包括代谢综合征、DM和血脂异常。虽然OSA和β-促细胞生成素存在共同的异常情况，但它们之间的关系尚未得到研究。
本研究旨在探讨β-促细胞生成素、OSA和血清脂质谱之间的关系。
连续90例疑似OSA患者接受多导睡眠图（PSG）检查以确诊OSA。分析血浆β-促细胞生成素、瘦素、脂联素和全血脂谱。根据呼吸暂停低通气指数（AHI）将患者分为OSA组或对照组。
约61%的患者患有OSA，39%的患者PSG正常。与对照组（分别为141.86±26.20、205.53±14.75和7.52±1.02μg/mL）相比，OSA患者的β-促细胞生成素、瘦素和脂联素水平更高（分别为256.59±29.35、374.20±37.93和17.86±2.63μg/mL）。β-促细胞生成素水平与AHI、瘦素相关（P = 0.413，P = 0.002，r = 0.782，P = 0.000）。与对照组相比，OSA患者的TG水平显著更高，高密度脂蛋白胆固醇（HDL-C）水平更低（分别为244±20.33 vs. 138±14.89，以及37.21±1.26 vs. 43.78±1.62）。TG水平与β-促细胞生成素相关（P = 0.353，P = 0.013）。多元回归分析显示，AHI、瘦素和觉醒是β-促细胞生成素水平的独立预测因素（B = 1.70，P = 0.046，95%置信区间；B = 0.56，P < 0.005；B = 1.2，P = 0.003）。
我们的结果表明OSA、β-促细胞生成素、TG和HDL以及其他脂肪因子之间存在复杂的关系。我们的结果需要进一步研究以评估这种复杂的关联并重新评估以前的相关研究。
