窄谱中波紫外线光疗与补骨脂素加长波紫外线化学光疗对越南银屑病患者的疗效比较
Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients.
作者信息
Van Thuong Nguyen, Van Tam Hoang, Minh Phuong Pham Thi, Trong Hao Nguyen, Van Tro Chau, Huu Nghi Dinh, Thi Thao Pham, Thu Hien Do Thi, Cam Van Tran, Huyen My Le, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
机构信息
National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Hanoi Medical University, Vietnam.
出版信息
Open Access Maced J Med Sci. 2019 Jan 25;7(2):227-230. doi: 10.3889/oamjms.2019.057. eCollection 2019 Jan 30.
BACKGROUND
Psoralen UVA (PUVA) and narrow-band UVB (NBUVB) chemophototherapy are treatment options for psoriasis.
AIM
To compare the effectiveness of NBUVB with PUVA in Vietnamese psoriasis patients.
METHODS
We conducted a non-randomized trial on 60 patients with plaque-type psoriasis (30 NBUVB, 30 PUVA). Both regimens were thrice-weekly. The extent of lesion was assessed by the Psoriasis Area Severity Index (PASI). Clearance was defined as a ≥ 75% reduction in a follow-up PASI score from baseline. Patients with clearance were followed-up until 6 months after stopping treatment. Relapse was defined as 50% or more of the original extent.
RESULTS
The proportion of patients achieving PASI75 was comparable (76.7% in NBUVB versus 80% in PUVA; p > 0.05). Patients in both groups had a similar number of sessions to achieve clearance but patients in the PUVA group exposed to a significantly higher cumulative UV dose. After six months, the relapse rate was higher in the NBUVB group compared with in the PUVA group (p > 0.05).
CONCLUSION
Thrice weekly NBUVB is as effective as thrice weekly PUVA in treating psoriasis for Vietnamese patients.
背景
补骨脂素长波紫外线（PUVA）和窄谱中波紫外线（NBUVB）化学光疗是治疗银屑病的方法。
目的
比较NBUVB与PUVA对越南银屑病患者的疗效。
方法
我们对60例斑块型银屑病患者进行了一项非随机试验（30例接受NBUVB治疗，30例接受PUVA治疗）。两种治疗方案均为每周3次。通过银屑病面积和严重程度指数（PASI）评估皮损范围。清除定义为随访时PASI评分较基线降低≥75%。对达到清除的患者随访至停止治疗后6个月。复发定义为皮损范围达到原来的50%或更多。
结果
达到PASI75的患者比例相当（NBUVB组为76.7%，PUVA组为80%；p>0.05）。两组患者达到清除所需的治疗次数相似，但PUVA组患者接受的累积紫外线剂量明显更高。6个月后，NBUVB组的复发率高于PUVA组（p>0.05）。
结论
对于越南患者，每周3次的NBUVB治疗银屑病的效果与每周3次的PUVA相当。
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