Van Em Dang, Diem Thuy Pham, Thi Van Bui, Xuan Tam Huynh Thi, Tuan Khai Ly, Quynh Trang Nguyen, Thu Trang Vu, Van Thuong Nguyen, Huu Sau Nguyen, Minh Phuong Pham Thi, Huu Nghi Dinh, Van Tam Hoang, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
108 Institute of Clinical Medicine and Pharmaceutical Sciences, Hanoi, Vietnam.
Kien Giang General Hospital, Rach Gia, Vietnam.
Open Access Maced J Med Sci. 2019 Jan 27;7(2):253-255. doi: 10.3889/oamjms.2019.065. eCollection 2019 Jan 30.
To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018.
We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI).
The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05.
NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone.
比较2016年5月至2018年5月期间，窄谱中波紫外线（NBUVB）联合口服甲氨蝶呤（MTX）与单独口服MTX治疗越南银屑病患者的疗效。
我们对70例中度至重度斑块型银屑病患者进行了一项非随机试验。35例患者每周5天，每天照射一次NBUVB，共4周，同时口服MTX 7.5mg/周；另外35例患者仅口服MTX 7.5mg/周，两组均治疗3个月。采用银屑病面积和严重程度指数（PASI）评估皮损范围。
PASI降低的比例相当（NBUVB联合MTX组为68.49%，单独MTX组为57.62%）；p<0.05。其中，NBUVB联合MTX组显效28.58%、有效68.57%、无效2.85%，优于单独MTX组的显效2.85%、有效71.4%、无效25.72%；p<0.05。NBUVB联合MTX组24个月后的复发率（42.9%）低于单独MTX组（71.4%）；p<0.05。
NBUVB联合口服MTX治疗慢性斑块型银屑病的效果优于单独口服MTX。
