越南补骨脂素加长波紫外线疗法的衰落：窄谱中波紫外线对越南白癜风患者的有效治疗
The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients.
作者信息
Thu Hien Do Thi, Hong Nhung Do Thi, Van Thuong Nguyen, Minh Phuong Pham Thi, Van Tam Hoang, Huu Nghi Dinh, Trong Hao Nguyen, Van Tro Chau, Ngoc Trai Nguyen, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
机构信息
National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Hong Ngoc General Hospital, Vietnam.
出版信息
Open Access Maced J Med Sci. 2019 Jan 28;7(2):256-258. doi: 10.3889/oamjms.2019.068. eCollection 2019 Jan 30.
AIM
To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.
METHODS
We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm and 150 mJ/cm, respectively, with 50 mJ/cm and 20 mJ/cm dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Response to therapy was assessed based on VASI score changes.
RESULTS
Based upon our results, 38.7% (12/31) of patients achieved a very good response of more than 50% VASI changes, 41.9% (13/31) obtained a good response (VASI changed from 25 to 50%). Total good and very good response to therapy significantly increased with prolonged treatment, increasing from 19.4% to 64.5% and 80.6% after 2, 4 and 6 months, respectively. Localised NSV patients obtained good and very good response significantly more frequently than generalised NSV (55.6% versus 18.2%). Adverse effects were minimal, of which one case developed herpes simplex, and 4 cases reported mild photo burn reaction which completely disappeared after adjusting the dose.
CONCLUSION
NB-UVB therapy is an effective and safe tool in the management of Vietnamese vitiligo patients.
目的
探讨窄谱中波紫外线（NB-UVB）治疗越南白癜风患者的疗效和安全性。
方法
我们招募了31例患者（14例男性，17例女性），年龄在7至67岁之间，患有节段性白癜风（SV）和非节段性白癜风（NSV），每周接受3次NB-UVB治疗。15岁及以上成人和15岁以下儿童的起始剂量分别为200 mJ/cm²和150 mJ/cm²，随后每次就诊剂量分别增加50 mJ/cm²和20 mJ/cm²，直至患者报告出现持续时间少于24小时的轻度红斑，治疗为期6个月。根据白癜风面积评分指数（VASI）变化评估治疗反应。
结果
根据我们的结果，38.7%（12/31）的患者达到了VASI变化超过50%的非常好的反应，41.9%（13/31）的患者获得了良好的反应（VASI变化从25%至50%）。随着治疗时间的延长，治疗的总良好和非常好反应显著增加，在2、4和6个月后分别从19.4%增加到64.5%和80.6%。局限性NSV患者获得良好和非常好反应的频率明显高于泛发性NSV患者（55.6%对18.2%）。不良反应极少，其中1例发生单纯疱疹，4例报告有轻度光灼伤反应，调整剂量后完全消失。
结论
NB-UVB疗法是治疗越南白癜风患者的一种有效且安全的方法。
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