Meyer zum Gottesberge A M
Department of Otorhinolaryngology, University of Düsseldorf, West Germany.
Acta Otolaryngol Suppl. 1988;460:18-27. doi: 10.3109/00016488809125131.
In this paper the current state of knowledge of the development in experimental endolymphatic hydrops (EEH) is summarized, with particular emphasis on calcium. An imbalanced Ca2+ homeostasis in the inner ear is demonstrated using EEH as an animal model for Meniere's disease. The possibility of a receptor-mediated Ca2+ transport across the epithelial layer, especially the light cells, and of 'chemical signal' as an initiating modulating factor in the disturbance of Ca2+ homeostasis was suggested. It is pointed out that melanin is capable of binding calcium and may act as a buffering system. Finally, the possible malfunction of the Ca-overloaded melanocytes on the inner ear function is discussed.
本文总结了实验性内淋巴积水（EEH）发展的当前知识状态，特别强调了钙。以内淋巴积水作为梅尼埃病的动物模型，证明了内耳中Ca2+稳态失衡。提出了受体介导的Ca2+跨上皮层（尤其是亮细胞）转运以及“化学信号”作为Ca2+稳态紊乱起始调节因子的可能性。指出黑色素能够结合钙并可能作为一种缓冲系统。最后，讨论了钙超载的黑素细胞对内耳功能可能产生的故障。
